Analysis of calcium-dependent adaptor function of apoptosis-associated protein ALG-2
Analysis of calcium-dependent adaptor function of apoptosis-associated protein ALG-2
批准号:
20380059
负责人:
MAKI Masatoshi
金额:
$12.4万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
X-ray crystal structure of the complex between the Ca^<2+>-binding protein ALG-2 and the binding peptide of its interacting protein Alix was resolved, and the molecular basis of the Ca^<2+>-dependent binding was elucidated. The ALG-2 dimer has one binding site in its monomer molecule, and was found to function as an adaptor to bridge Alix and TSG101 in the presence of Ca^<2+>. It was also found that ALG-2 bridges Sec31A and annexin A11.
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Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2^<ΔGF122>) and structural roles of F122 in target recognition
ALG-2 (ALG-2^<ΔGF122>) 选择性剪接亚型导致 Alix 结合缺陷的分子基础以及 F122 在目标识别中的结构作用
DOI:
--
发表时间:
2010
期刊:
BMC Structural Biology
影响因子:
--
作者:
[Inuzuka T, Suzuki H, Kawasaki M, Shibata M, Wakatsuki S, Maki M]
通讯作者:
Maki M
バイオインフォマティクス的手法を用いた新規ALG-2相互作用因子の探索
使用生物信息学方法寻找新的 ALG-2 相互作用因子
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[大杉桂奈江, 外5名]
通讯作者:
外5名
Crystallization and X-ray diffraction analysis of N-terminally truncated human ALG-2
N 末端截短的人 ALG-2 的结晶和 X 射线衍射分析
DOI:
--
发表时间:
2008
期刊:
Acta Crystallogr F
影响因子:
0.9
作者:
[Suzuki H, Kawasaki M, Kakiuchi T, Shibata H, Wakatsuki S, Maki, M]
通讯作者:
M
ALG-2結合モチーフに基づいた新規ALG-2相互作用因子の探索
基于 ALG-2 结合基序寻找新型 ALG-2 相互作用因子
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大杉桂奈江, 外5名]
通讯作者:
外5名
ミトコンドリア局在型リン脂質scramblase 3の細胞内局在に対するパルミトイル化の影響
棕榈酰化对线粒体定位磷脂扰乱酶 3 亚细胞定位的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[犬塚達俊, 猪川亮, 木津久美子, 柴田秀樹, 成田宏史, 牧正敏, 犬塚達俊, 犬塚達俊, 犬塚達俊, 犬塚達俊, 犬塚達俊]
通讯作者:
犬塚達俊
共 31 条
Elucidation of physiological functions of the EF-hand protein ALG-2 as a calcium-stress response factor
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批准号:17H03803
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.23万
-
财政年份:2017
-
负责人:MAKI Masatoshi
-
依托单位:
Regulatory mechanism of adipocyte differentiation by PLSCR3 mediated by extracellularly secreted vesicle exosomes
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批准号:25660076
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
-
财政年份:2013
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负责人:MAKI Masatoshi
-
依托单位:
Roles of calcium-dependent adaptor protein ALG-2 in regulation of intracellular delivery system
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批准号:23380056
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2011
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负责人:MAKI Masatoshi
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依托单位:
The mechanism of the Action of the calcium-binding protein ALG-2on the regulation of cell membrane receptor sorting
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批准号:17380063
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.11万
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财政年份:2005
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负责人:MAKI Masatoshi
-
依托单位:
Mechanism of regulation of programmed cell death by intracellular calcium-binding protein ALG-2
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批准号:14360051
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
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财政年份:2002
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负责人:MAKI Masatoshi
-
依托单位:
Functional analysis of a novel intracellular calcium-binding protein peflin
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批准号:11460038
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.94万
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财政年份:1999
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负责人:MAKI Masatoshi
-
依托单位:
Biochemical analysis of the novel tumor suppressor gene product RECK
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批准号:08660101
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
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财政年份:1996
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负责人:MAKI Masatoshi
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依托单位:
Identification of endogenous calcium channel activator and develpment of clinical analysis method by spedific antibodies.
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批准号:03557108
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$8.38万
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财政年份:1991
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负责人:MAKI Masatoshi
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依托单位:
Studies on Regulation of Cellular Function by Calpastatin
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批准号:01580157
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1989
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负责人:MAKI Masatoshi
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依托单位:
海外基金