Regulation of acquired immunity via negative feedback mechanism between dendritic cells and NK-T cells

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We demonstrated that balances of cytokines are negatively or positively regulated in dendritic cells with a unique combination such as IL-12/23 production by prostaglandin E2, IL-10 by TNF-α, and IL-33 by noradrenalin. We also found that NK-T cells (especially type II subset) play an accelerating role in visceral fat syndrome. In atherosclerotic model, CD1d-restricted NKT cell subset seemed to be negatively regulated by MR1-restricted NKT cell subset.