Translational research for establishment of heavy ion radiotherapy for cancer

建立癌症重离子放射治疗的转化研究

• 批准号: 20390324
• 负责人: NAKANO Takashi
• 金额: $ 11.9万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390324/
• 关键词: 重粒子線; 放射線治療; 放射線生物学; 粒子線治療; 放射線腫瘍学

1) Carbon-ion beams were about 10-fold more effective than X-rays in immature hippocampal neurons. X-irradiation immediately induced morphological changes in axons and dendrite. These changes seemed to be caused by x-irradiation evoking depolymerization of microfilament. 2) Under severe hypoxic condition for 1 hour, oxygen enhancement ratio (OER) of X-ray was calculated as 2.7. Under severe hypoxic condition for 24 hour, OER of X-ray was decreased from 2.6 to 1.1 by addition of mTOR inhibitor but, OER was not changed in carbon-ion beam irradiation. 3) The RBE of C-beams to X-rays in the normal cerebellum of infant rats with rat organotypic slice culture system was assumed to be 1.4.4) Radiation-induced ICAM-1 expression on HUVE cells was regulated by TGF-β1 and carbon-beam induced higher ICAM-1 expression than X-ray. 5) HIF-1α expression was a prognostic factor in patients with locally advanced rectal cancer. 6) The cost-effectiveness of carbon beam therapy was good for advanced rectal cancers and lung cancers by analyzing clinical data.

1)碳离子束对未成熟海马神经元的作用比X射线强10倍。X射线照射后立即引起轴突和树突的形态学变化。这些变化似乎是由x射线照射引起的微丝解聚。2)在重度低氧条件下1h，计算X线的氧增强比（OER）为2.7。在严重低氧条件下24小时，加入mTOR抑制剂后，X射线的OER从2.6下降到1.1，而碳离子束照射的OER没有变化。3)在大鼠器官型脑片培养系统中，C-射线对正常幼年大鼠小脑的相对生物效应（RBE）为1.4。4）辐射诱导HUVE细胞ICAM-1表达受TGF-β1调节，C-射线诱导的ICAM-1表达高于X-射线。5)HIF-1α表达是局部进展期直肠癌患者的预后因素。6)通过临床资料分析，碳束治疗晚期直肠癌和肺癌的成本-效果良好。

项目成果

Radiation-induced ICAM-1 expression via TGF-β1 pathway on human umbilical vein endothelial cells ; comparison between X-ray and carbon-ion beam jrradiation

X射线与碳离子束照射通过TGF-β1途径辐射诱导人脐静脉内皮细胞ICAM-1表达的比较

• 发表时间: 2011
• 期刊: J Radiat Res
• 影响因子: 2
• 作者: Hiroki KIYOHARA;et al
• 通讯作者: et al

Direct visualization and quantification of the anticancer agent, cis-diamminedichloro-pla!tinum(II), in human lung cancer cells using in-air microparticle-induced X-rav emission analysis.

使用空气微粒诱导的 X 射线发射分析对人肺癌细胞中的抗癌剂顺式二氨二氯铂 (II) 进行直接可视化和定量。

• 发表时间: 2008
• 期刊: Cancer Sci 99(5)
• 作者: Sakurai H;Okamoto M;Hasegawa M;Satoh T;Oikawa M;Kamiya T;ArakawaK;Nakano T
• 通讯作者: Nakano T

Evaluation of the relative biological effectiveness of carbon ion beams in the cerebellum using the rat organotypic slice culture system.

• DOI: 10.1269/jrr.11139a
• 发表时间: 2012
• 期刊: Journal of radiation research
• 影响因子: 2
• 作者: Y. Yoshida;Yoshiyuki Suzuki;W. Al-jahdari;N. Hamada;T. Funayama;K. Shirai;H. Katoh;T. Sakashita;Y. Kobayashi;T. Nakano

Proliferation and cell death of human glioblastoma cells after carbon-ion beam exposure: Morphologic and morphometric analyses

• DOI: 10.1111/j.1440-1789.2008.00899.x
• 发表时间: 2008-08-01
• 期刊: NEUROPATHOLOGY
• 影响因子: 2.3
• 作者: Oishi, Takuma;Sasaki, Atsushi;Nakazato, Yoichi
• 通讯作者: Nakazato, Yoichi

Growth Cone Collapse and Neurite Retractions: An Approach to Examine X-irradiation Affects on Neuron Cells

• DOI: 10.1269/jrr.08013
• 发表时间: 2008-09-01
• 期刊: JOURNAL OF RADIATION RESEARCH
• 影响因子: 2
• 作者: Al-Jahdari, Wael S.;Suzuki, Yoshiyuki;Nakano, Takashi
• 通讯作者: Nakano, Takashi