Basic research on Sophistication of Medical Si/CdTe compton camera

医用Si/CdTe康普顿相机精密度基础研究

• 批准号: 24659557
• 负责人: NAKANO Takashi
• 金额: $ 2.33万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659557/
• 关键词: コンプトンカメラ; 粒子線治療; 核医学診断; 国際研究者交流

We developed Si/CdTe Compton camera for medical use which can measure gannma-rays from the Tc-99m up to F-18. Then, we succeeded simultaneously to measure two types of RI distributions of F-18FDG and I-133 and to obtain three-dimensional imaging of the two RI distribution administered to a rat.We succeeded to conduct clinical study of administration of 18F-FDG and 99mTc-DMSA, drugs for nuclear medicine diagnostic, in a human to obtain simultaneous imaging of the two RI by the clinical Si/CdTe Compton camera first in the world. In clinical, by simultaneous measurement method by multiple RI drugs, a significant reduction in testing time is expected. In addition, the development of RI diagnostic techniques of tracing simultaneous disposition of multiple RI drugs is expected to lead to the creation of a new scientific area such as bio-dynamics study by the tracing and the study to clarify the mechanisms of malignant transformation of cancer cells.

我们研制了医用硅/碲化镉康普顿照相机，它可以测量从Tc-99 m到F-18的γ射线。然后，我们成功地同时测量了F-18 FDG和I-133的两种类型的RI分布，并获得了给予大鼠的两种RI分布的三维成像。我们成功地进行了给予18 F-FDG和99 mTc-DMSA的临床研究，在临床上首次用Si/CdTe康普顿照相机对两种RI同时成像。在临床上，通过多种RI药物的同时测量方法，预期显著减少测试时间。此外，开发的RI诊断技术的跟踪多个RI药物的同时处置，预计将导致创建一个新的科学领域，如生物动力学研究的跟踪和研究，以澄清癌细胞的恶性转化的机制。

项目成果

Differential bystander signaling between radioresistant chondrosarcoma cells and fibroblasts after x-ray, proton, iron ion and carbon ion exposures.

• DOI: 10.1016/j.ijrobp.2012.02.052
• 发表时间: 2012-09
• 期刊: International journal of radiation oncology, biology, physics
• 作者: M. Wakatsuki;Nicole Magpayo;H. Kawamura;K. Held

群馬大学における重粒子線マイクロサージェリィ治療技術の開発について

关于群马大学重离子束显微外科治疗技术的开发

• 发表时间: 2012
• 作者: O'Sullivan T;Saddawi-Konefka R;Gross E;Tran M;Mayfield SP;Ikeda H;Bui JD.;菊知充;中野隆史
• 通讯作者: 中野隆史

Usefulness of double dose contrast-enhanced magnetic resonance imaging for clear delineation of gross tumor volume in stereotactic radiotherapy treatment planning of metastatic brain tumors: a dose comparison study.

• DOI: 10.1093/jrr/rrs053
• 发表时间: 2013-01
• 期刊: Journal of radiation research
• 影响因子: 2
• 作者: Subedi KS;Takahashi T;Yamano T;Saitoh J;Nishimura K;Suzuki Y;Ohno T;Nakano T
• 通讯作者: Nakano T

医学用Si/CdTe半導体コンプトンカメラの体幹部における散乱が画質に与える影響

医用Si/CdTe半导体康普顿相机体内散射对图像质量的影响

• 发表时间: 2014
• 作者: Subedi KS;Takahashi T;Yamano T;Saitoh JI;Nishimura K;Suzuki Y;Ohno T;Nakano T.;酒井真理,菊地美貴子,鳥飼幸太,荒川和夫,山口充孝,長尾悠人,河地有木,藤巻秀,神谷富裕,小高裕和,国分紀秀,武田伸一郎,渡辺伸,高橋忠幸,中野隆史
• 通讯作者: 酒井真理,菊地美貴子,鳥飼幸太,荒川和夫,山口充孝,長尾悠人,河地有木,藤巻秀,神谷富裕,小高裕和,国分紀秀,武田伸一郎,渡辺伸,高橋忠幸,中野隆史

Three-dimensional and multienergy gamma-ray simultaneous imaging by using a Si/CdTe Compton camera.

使用 Si/CdTe 康普顿相机进行三维多能伽马射线同步成像。

• 发表时间: 2013
• 期刊: Radiology
• 影响因子: 19.7
• 作者: Suzuki Y;Yamaguchi M;Odaka H;Shimada H;Yoshida Y;Torikai K;Satoh T;Arakawa K;Kawachi N;Watanabe S;Takeda S;Ishikawa SN;Aono H;Watanabe S;Takahashi T;Nakano T.
• 通讯作者: Nakano T.