Clarification for the central regulation of physical fatigue

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The central mechanisms to regulate physical fatigue were examined using magnetoencephalographic (MEG), electrocardiographic (ECG), and psycho-behavioral techniques in healthy participants. By using Ramachandran's mirror box, we identified behavioral and neural evidence of an inhibitory system to limit the activation of the contralateral sensorimotor area during physical fatigue. In addition, the prefrontal area was shown to be a brain region associated with the compensation mechanisms to enhance the bilateral sensirimotor areas. Hence, we have obtained precious clues for the comprehensive understanding of the central mechanisms to regulate physical fatigue.