Molecular analysis of iron -sulfur cluster biosynthesis machinery : Reaction mechanism based on conformational transition of IscU
Molecular analysis of iron -sulfur cluster biosynthesis machinery : Reaction mechanism based on conformational transition of IscU
批准号:
20570130
负责人:
TAKAHASHI Yasuhiro
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Proteins containing Fe-S clusters are called Fe-S proteins and participate in a wide range of cellular processes from energy metabolism to gene regulation. The assembly of Fe-S clusters is achieved by a multicomponent machinery. In this study, we have characterized the IscU protein that plays a central role in the biosynthesis machinery and revealed its functionality based on the unique structure.
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鉄硫黄クラスターの生合成を担うタンパク質複合俸の構造とダイナミズム
负责铁硫簇生物合成的蛋白质复合物的结构和动力学
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[瀧森祥太, 島岡秀之, 天野麻穂, 山下匡, 篠原康郎, Kacskovics Imre, 西村紳一郎, 高橋康弘]
通讯作者:
高橋康弘
The asymmetric architecture of 2Fe-2S IscU, a scaffold protein for iron-sulfur cluster biosynthesis
铁硫簇生物合成支架蛋白2Fe-2S IscU的不对称结构
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[K.Fukuyama, K.Wada, Y. Shimomura, Y.Takahashi]
通讯作者:
Y.Takahashi
Structural Studies on the Fe-S Cluster-bound Holo-form of IscU.
IscU 的 Fe-S 簇束缚全息形式的结构研究。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Takahashi, Y., Shimomura, Y., Wada, K., Fukuyama, K.]
通讯作者:
K.
IscR regulates RNase LS activity by repressing rn1A transcription
IscR 通过抑制 rn1A 转录来调节 RNase LS 活性
DOI:
--
发表时间:
2010
期刊:
Genetics
影响因子:
3.3
作者:
[Niimi K, Nishioka C, Miyamoto T, Takahashi E, Miyoshi I, Itakura C, Yamashita T., Yuichi Otsuka]
通讯作者:
Yuichi Otsuka
Molecular dynamism of Fe-S cluster biosynthesis implicated by the structure of SufC2-SufD2 complex.
SufC2-SufD2 复合物结构涉及 Fe-S 簇生物合成的分子动力学。
DOI:
--
发表时间:
2009
期刊:
J.Mol.Biol. 387
影响因子:
--
作者:
[Wada, Kei]
通讯作者:
Kei
共 32 条
Elucidation of molecular mechanism of the SufBCD complex responsible for biosynthesis of iron-sulfur cluster and development of its inhibitor
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批准号:15H04472
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.9万
-
财政年份:2015
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负责人:TAKAHASHI Yasuhiro
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依托单位:
LSI design of secure and low-power adiabatic logic
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批准号:24760274
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.25万
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财政年份:2012
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负责人:TAKAHASHI Yasuhiro
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依托单位:
Molecular mechanism of the supramolecular machinery involved in biosynthesis of labile iron-sulfur clusters
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批准号:24570148
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.58万
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财政年份:2012
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负责人:TAKAHASHI Yasuhiro
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依托单位:
A comparative study of the English colonies between Virginia and New England
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批准号:21520244
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.08万
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财政年份:2009
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负责人:TAKAHASHI Yasuhiro
-
依托单位:
Iron-sulfur cluster biosynthesis : Molucular mechanism of the assembly of intermediate cluster and its transfer to apo proteins.
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批准号:17570112
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:TAKAHASHI Yasuhiro
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依托单位:
Mechanism of iron-sulfur cluster biosynthesis : Analysis of a framework and the reaction mechanism for the two iron-sulfur cluster assembly systems.
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批准号:15510174
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2003
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负责人:TAKAHASHI Yasuhiro
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依托单位:
Mechanism of iron-sulfur cluster assembly : Structure and functional interaction of Isc proteins
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批准号:13680690
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2001
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负责人:TAKAHASHI Yasuhiro
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依托单位:
Molecular Biochemical Study on the Cyanobacterial ndh (NADH dehydrogenase) Gene Products
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批准号:06640840
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1994
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负责人:TAKAHASHI Yasuhiro
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依托单位:
Structure and Disorder of Fibrous Substance including Silk and Cellulose
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批准号:62470096
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1987
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负责人:TAKAHASHI Yasuhiro
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依托单位:
海外基金