Inhibitory mechanism of lenthionine against platelet aggregation and biological activity of its inclusion complex in α-cyclodextrin

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We analyzed the mechanism of the inhibitory effect of lenthionine, cyclic sulfuric flavor component in shiitake, against platelet aggregation. In addition, we attempted to reduce its odor and enhance its solubility in water by the inclusion of lenthionine in α-cyclodextrin. Lenthionine suppressed phospholylation of talin, morphological change in platelets, and activation of integrin αIIbβ3. Inclusion of lenthionine by α-cyclodextrin reduced its characteristic odor and enhanced its solubility in water. Lenthionine included in α-cyclodextrin inhibited platelet aggregation ex vivo.