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Regulation of the onset of atopic asthma-like phenotype by microorganisms (virus-mimetics)

Regulation of the onset of atopic asthma-like phenotype by microorganisms (virus-mimetics)
微生物(病毒模拟物)调节特应性哮喘样表型的发作
批准号:
20590062
负责人:
TANAKA Hiroyuki
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
In the present study, we examined the effect of intratracheal administration of double-stranded RNA (dsRNA), produced during virus replication, prior to the repeated instillation of mite extract into the airways on the development of asthma-like phenotypes by in mice. As a result, a lower amount of dsRNA augmented the onset of asthma-like phenotypes, whereas a higher dose of dsRNA inhibited the development of the pathophysiological changes. These effects by dsRNA are dependent of CD8+T cells and IL-13 or CD8+T cells and IFN-g, respectively. Furthermore, we demonstrated that these modifications by dsRNA were not dependent on TLR3, TLR4 or MDA-5.
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環境因子による喘息様病態形成への影響-マウスモデルを用いた検討から-
环境因素对哮喘样病理形成的影响 - 来自使用小鼠模型的研究 -
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Terui, Y., Higashi, K., Tabei, Y., Tomitori, H., Yamamoto, K., Ishihama, A., Igarashi, K., Kashiwagi, K., 田中宏幸]
通讯作者: 田中宏幸
Immunomodulatory Effects of CpG Oligodeoxynucleotides on House Dust Mite-Induced Airway Inflammation in Mice.
CpG 寡脱氧核苷酸对屋尘螨诱发的小鼠气道炎症的免疫调节作用。
DOI: --
发表时间: 2008
期刊: Int Arch Allergy Immunol 147
影响因子: --
作者: [Hirose I, Tanaka H, et al.]
通讯作者: et al.
Immunomodulatory Effects of CpG 0ligodeoxynucleotides on House Dust Mite-Induced Airway Inflammation in Mice.
CpG 0 寡脱氧核苷酸对屋尘螨诱发的小鼠气道炎症的免疫调节作用。
DOI: --
发表时间: 2008
期刊: Int. Arch. Allergy Immunol. 147
影响因子: --
作者: [Hirose I, et al.]
通讯作者: et al.
DOI: 10.4049/jimmunol.180.9.6262
发表时间: 2008-05-01
期刊: JOURNAL OF IMMUNOLOGY
影响因子: 4.4
作者: [Nakao, Isao, Kanaji, Sachiko, Izuhara, Kenji]
通讯作者: Izuhara, Kenji
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