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Development of a drug delivery carrier of paclitaxel to cancer cells using a bispecific single chain Fv

Development of a drug delivery carrier of paclitaxel to cancer cells using a bispecific single chain Fv
使用双特异性单链 Fv 开发紫杉醇至癌细胞的药物递送载体
批准号：
22501046
负责人：
TANAKA Hiroyuki
金额：
$2.75万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22501046/
关键词：
L-amino acid transporter I (LAT1)パクリタキセルミサイル療法二重特異性抗体小型化抗体癌LATI薬物送達

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中文摘要
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英文摘要
In this study, anti-paclitaxel (PAC) scFv was successfully prepared and combined with anti-Her2 or LAT1 scFv. The yield of the bispecific scFv was sufficientwith an expression system using Escherichia coli.. The expressed bispecific scFv was purified and evaluated contribution of anti-cancer property. On in vitro assay, we treated some cancer cells with PAC and the bispecific scFv. However, there is no significant difference between this experimental condition and the control regarding anti-cancer activity. We will verify the refolding system of the bispecific antibody to give more stable activity, and in addition, we will modify structure of recombinant antibodies for application of a drug delivery system.
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Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel
DOI： 10.1007/s11418-012-0708-1
发表时间： 2013-07-01
期刊： JOURNAL OF NATURAL MEDICINES
影响因子： 3.3
作者： [Chao, Zhi, Tan, Mingming, Morimoto, Satoshi]
通讯作者： Morimoto, Satoshi
組換え抗paclitaxel Fabの構築とその機能評価
重组抗紫杉醇Fab的构建及其功能评价
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [田中宏幸, 田畑香織、森元 聡]
通讯作者： 田畑香織、森元 聡
A Fundamental Study on the Theory of Sovereignty and Taxing Power
Research and Development of the Moral Education Units in use of the Moral Competencies Questionare and Postcard Newspapers
  • 批准号：
    19K02515
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
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  • 财政年份：
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  • 负责人：
    TANAKA Hiroyuki
  • 依托单位：
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  • 项目类别：
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  • 资助金额：
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  • 财政年份：
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  • 负责人：
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