Novel function of histamine in atherosclerotic artery

组胺在动脉粥样硬化中的新功能

• 批准号: 20590416
• 负责人: TANIMOTO Akihide
• 金额: $ 3.08万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590416/
• 关键词: 動脈硬化; ヒスタミン; ヒスタミンレセプター(HR); ヒスチジン脱炭酸酵素; HDC; apoE-KOマウス; HR; スカベンジャー受容体; 炎症因子; ヒスチジン脱炭酸酵素(HDC); HDC/apoE-KOマウス; HR/apoE-KOマウス; ヒスタミンレセプター

The relation of histamine signaling in the arterial wall and atherogenesis was investigated using apoE-H1R-KO, apoE-H2R-KO and apoE-HDC-KO mice. The mice were fed by high cholesterol diet (1.25% cholesterol, 15% lard and 0.5% cholic acid) for 12 weeks, and pathological examination and expression of inflammation-related genes were evaluated in the aortas. Even the high cholesterol diet induced much higher hypercholesterolemia in apoE-H2R-KO and apoE-HDC-KO mice, the atherosclerotic lesion formation and expression of many inflammation-related genes were reduced in these KO mice than in apoE-KO mice. The histamine signaling mediated through H2 receptor would play a pivotal role in atherogenesis by regulating the inflammatory response in the vascular wall.

用apoE-H1R-KO、apoE-H2R-KO和apoE-HDC-KO小鼠研究动脉壁组胺信号与动脉粥样硬化形成的关系。以高胆固醇饲料(1.25%胆固醇、15%猪油、0.5%胆酸)喂养12周，观察大鼠主动脉组织病理改变及炎症相关基因的表达。即使高胆固醇饮食导致apoE-H 2R-KO和apoE-HDC-KO小鼠的高胆固醇血症，这些KO小鼠的动脉粥样硬化病变的形成和许多炎症相关基因的表达也比apoE-KO小鼠减少。H2受体介导的组胺信号转导可能通过调节血管壁的炎症反应在动脉粥样硬化形成中发挥关键作用。

项目成果

Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice.

• DOI: 10.2353/ajpath.2010.091198
• 发表时间: 2010-08
• 期刊: The American journal of pathology
• 作者: Ke-Yong Wang;A. Tanimoto;S. Yamada;Xin Guo;Yan Ding;Teruo Watanabe;Takeshi Watanabe;K. Kohno;K. Hirano;H. Tsukada;Y. Sasaguri

Role of histamine in atherosclerotic lesion.

组胺在动脉粥样硬化病变中的作用。

• 发表时间: 2010
• 期刊: J UOEH. 32(Review)
• 作者: Wang KY;Tanimoto A;Sasaguri Y.
• 通讯作者: Sasaguri Y.

粥状動脈硬化におけるヒスタミン受容体(HH1R、HH2R)の役割

组胺受体（HH1R、HH2R）在动脉粥样硬化中的作用

• 发表时间: 2010
• 作者: 王克よう;谷本昭英;他
• 通讯作者: 他

Histamine deficiency decreases atherosclerosis and inflammatory response in apoE-KO mice independently on serum cholesterol level.

组胺缺乏可降低 apoE-KO 小鼠的动脉粥样硬化和炎症反应，与血清胆固醇水平无关。

• 发表时间: 2011
• 期刊: Arterioscler Thromb Vasc Biol. in press
• 作者: Wang KY;Tanimoto A;Guo X;Yamada S;Shimajiri S;Murata Y;Ding Y;Tsutsui M;Kato S;Watanabe T;Ohtsu H;Hirano K;Kohno K;Sasaguri Y.
• 通讯作者: Sasaguri Y.

動脈硬化病変におけるヒスタミンの役割

组胺在动脉粥样硬化病变中的作用

• 发表时间: 2010
• 期刊: 産業医科大学雑誌 32
• 作者: 王克よう;谷本昭英;笹栗靖之
• 通讯作者: 笹栗靖之