Novel function of histamine in atherosclerotic artery

采用apoE-H1R-KO、apoE-H2R-KO和apoE-HDC-KO小鼠，研究了动脉壁组胺信号与动脉粥样硬化的关系。采用高胆固醇饲粮（1.25%胆固醇、15%猪油、0.5%胆酸）喂养12周，观察大鼠主动脉组织病理学检查及炎症相关基因表达情况。即使高胆固醇饮食导致apoE-H2R-KO和apoe - hdl -KO小鼠的高胆固醇血症更高，这些KO小鼠的动脉粥样硬化病变形成和许多炎症相关基因的表达也比apoE-KO小鼠减少。H2受体介导的组胺信号通过调节血管壁炎症反应在动脉粥样硬化中起关键作用。

The relation of histamine signaling in the arterial wall and atherogenesis was investigated using apoE-H1R-KO, apoE-H2R-KO and apoE-HDC-KO mice. The mice were fed by high cholesterol diet (1.25% cholesterol, 15% lard and 0.5% cholic acid) for 12 weeks, and pathological examination and expression of inflammation-related genes were evaluated in the aortas. Even the high cholesterol diet induced much higher hypercholesterolemia in apoE-H2R-KO and apoE-HDC-KO mice, the atherosclerotic lesion formation and expression of many inflammation-related genes were reduced in these KO mice than in apoE-KO mice. The histamine signaling mediated through H2 receptor would play a pivotal role in atherogenesis by regulating the inflammatory response in the vascular wall.