New therapy for diastolic heart failure from the standpoint of insulin resistance

从胰岛素抵抗的角度治疗舒张性心力衰竭的新疗法

• 批准号: 20590826
• 负责人: OGINO Kazuhide
• 金额: $ 2.5万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590826/
• 关键词: 糖代謝異常; 拡張不全; インスリン抵抗性; インスリン抗性

[Aim] (1) The effects of pioglitazone (PIO), benzbromarone (BENZ) and losartan (LOS) in CHF with insulin resistance (IR), (2) the effects of exercise and PIO in CHF mouse.[Results] PIO, BENZ and LOS improved inflammatory cytokines and IR in CHF. Serum uric acid level and inflammatory cytokines were correlated with IR. In CHF mouse, both PIO and exercise improved IR and cardiac function with the reduction of inflammatory cytokines and matrix metalloproteinases (MMPs).[Conclusion] There was relationship between IR and cardiac function in CHF, which may be mediated via inflammatory cytokines and MMPs.

[目的] (1) 吡格列酮 (PIO)、苯溴马隆 (BENZ) 和氯沙坦 (LOS) 对伴有胰岛素抵抗 (IR) 的 CHF 的影响，(2) 运动和 PIO 对 CHF 小鼠的影响。 [结果] PIO、BENZ 和 LOS 改善 CHF 中的炎症细胞因子和 IR。血清尿酸水平和炎症细胞因子与IR相关。在CHF小鼠中，PIO和运动均可改善IR和心功能，并减少炎症细胞因子和基质金属蛋白酶（MMP）。[结论]CHF小鼠IR与心功能存在相关性，可能是通过炎性细胞因子和MMP介导的。

项目成果

ACE阻害薬治療中の心不全におけるロサルタン追加投与のインスリン抵抗性に及ぼす影響

额外服用氯沙坦对 ACE 抑制剂治疗的心力衰竭患者胰岛素抵抗的影响

• 发表时间: 2011
• 作者: Okubo M;Kawasaki M;Ishihara Y;Takeyama U;Yasuda S;Kubota T;Tanaka S;Yamaki T;Ojio S;Nishigaki K;Takemura G;Saio M;Takami T;Fujiwara H;Minatoguchi S;荻野和秀
• 通讯作者: 荻野和秀

Uric Acid-Lowering Treatment With Benzbromarone in Patients With Heart Failure A Double-Blind Placebo-Controlled Crossover Preliminary Study

• DOI: 10.1161/circheartfailure.109.868604
• 发表时间: 2010-01-01
• 期刊: CIRCULATION-HEART FAILURE
• 影响因子: 9.7
• 作者: Ogino, Kazuhide;Kato, Masahiko;Doehner, Wolfram
• 通讯作者: Doehner, Wolfram

Matrix Metalloproteinases Were Produced in Failing Hearts and Were Decreased With Spironolactone in Patients With Chronic Heart Failure

基质金属蛋白酶是在衰竭的心脏中产生的，并且在慢性心力衰竭患者中使用螺内酯可以减少基质金属蛋白酶

• 发表时间: 2008
• 作者: Tanaka H;Ishida T;Johnston TP;Kojima Y;Yasuda T;Kundu RK;Quertermous T;Ishikawa Y;Hirata K;川崎雅規;荻野和秀
• 通讯作者: 荻野和秀

Matrix metalloproteinases were produced in failing hearts and were decreased with spironolactone in patients with chronic heart failure.

基质金属蛋白酶是在衰竭的心脏中产生的，并且在慢性心力衰竭患者中使用螺内酯可以减少基质金属蛋白酶。

• 发表时间: 2008
• 作者: 荻野和秀;加藤雅彦;久留一郎;重政千秋
• 通讯作者: 重政千秋

Matrix metalloproteinase were produced in failing hearts and were decreased with spironolactone in patients with chronic heart failure

基质金属蛋白酶在衰竭的心脏中产生，在慢性心力衰竭患者中螺内酯可降低基质金属蛋白酶的含量

• 发表时间: 2009
• 作者: Kojima Y;et al.;川崎雅規;荻野和秀
• 通讯作者: 荻野和秀