Elucidation of biofunctional expression mechanism of food polyphenols by oxidative modification of protein

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In the present study, we searched for polyphenols that covalently bind to cellular proteins. A major green tea catechin, epigallocatechin-3-gallate (EGCG), was identified to bind to cellular proteins with high affinity. The regulation mechanism of protein function by the binding of EGCG was examined. We also identified cellular protein targets of EGCG in several functional categories including energy metabolism, glycolysis, chaperone, and RNA processing. The binding of EGCG to the target protein was suggested to be closely involved in anti-cancer effect of EGCG.