Mechanisms of streptococcal infection investigated by whole genomic tiling array

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Genomic contents of group A streptococci is rich in A or T nucleotides. This causes problem in determination of transcription factors and/or prediction of open reading regions. Firstly, we have established the method to analyze the transcriptome of streptococcal cells inside host eukaryotic cells with cDNA microarray and tiling array. The data obtained from the arrays revealed the existence of 58 novel non-coding RNA and importance of unknown genes to combat with host immune system. These things suggests various pathogenicities of group A streptococci are resulted from these non-coding RNA and hypothetical genes.