Physiological function of PLCdelta3 in neuronal outgrowth

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Phospholipase Cd3 (PLCd3) is a key enzyme, which generates two second messengers including IP3 and DAG in phosphatidylinositol signaling and is highly expressed in neuronal tissues. We found that PLCd3 knockdown in cerebral cortex of E14 embryo by in utero electroporation caused the migratory inhibition of cortical neurons in developing cerebral cortex. Furthermore, we demonstrated that neuronal outgrowth was significantly inhibited in cerebellar granule cells or neuroblastoma cells when PLCd3 was transiently knockdowned during differentiation.