Effect of intravenous administration of immunoglobulin on myocardial reperfusion injury.

静脉注射免疫球蛋白对心肌再灌注损伤的影响。

• 批准号: 20790547
• 负责人: UENO Koji
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790547/
• 关键词: 免疫グロブリン; 虚血再潅流; 接着因子; 補体; 好中球; 虚血再潅流傷害; 左室リモデリング

Intravenous administration of immunoglobulin (IVIG) pretreatment before ischemia/reperfusion (I/R) attenuated microcirculatory disturbance and inflammatory response, and preserved left ventricular function. IVIG may be effective as an adjunctive therapy to myocardial reperfusion injury, possibly through inhibition of complementary system that plays an important role during the early stage of inflammatory cascades in I/R.

在缺血/再灌注（I/R）前静脉注射免疫球蛋白（IVIG）预处理可减轻微循环障碍和炎症反应，并保护左心室功能。IVIG可能通过抑制在I/R早期炎性级联反应中起重要作用的补体系统而对心肌再灌注损伤起到持续治疗作用。

项目成果

Intravenous administration of immunoglobulin attenuates myocardial reperfusion injury and improves left ventricular remodeling

静脉注射免疫球蛋白可减轻心肌再灌注损伤并改善左心室重构

• 发表时间: 2007
• 期刊: Circulation 116(Suppl)
• 作者: Ueno K;Anzai T;Jo Y;Naito K;Kohno T;Takahashi T;Yoshikawa T;Ogawa S.
• 通讯作者: Ogawa S.