Basical study for curing malignant brain tumor with carbon-ion beam therapy

碳离子束治疗恶性脑肿瘤的基础研究

• 批准号: 20790877
• 负责人: SUZUKI Yoshiyuki
• 金额: $ 2.58万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790877/
• 关键词: 炭素イオン線; 悪性脳腫瘍; 遊走能; 増感剤; ニューロン

1) According to the rate of radiation induced apoptosis, effect of Carbon-ion beam to immature neuron was about ten times higher than that of X-ray.2) As for glial cell, there was little difference in X-ray radiosensitivity between immature and mature cells. X-ray radiosensitivity of glial cell was a little low compared with that of neuronal cell.3) As for anti-tumor effect, the effect of X-ray with concurrent TMZ was 1.6 times higher than that without TMZ. Moreover, the effect of X-ray with concurrent TMZ and GYKI52466 was 10% higher than that with TMZ alone in the brain transplant model. As for RBE, when TMZ was used concurrently, the RBE of carbon-ion beam to X-ray was estimated about 3, similar to the RBE without TMZ in in vivo model. Also, the combinational effect of TMZ was an additive effect. As for cell motility, though the motility of tumor cell was enhanced by X-ray alone, it was completely controled by the use of ether TMZ or GYKI52466.4) Concurrent use of TMZ with carbon-ion beam did not enhance the radiation effect.5) Expression of Akt and PDK1 in malignant brain tumor cell were increased by X-ray irradiation and the increased expression of PDK1 correlated to activation of cell motility. In clinical, strong expression of activated Akt and PDK1 were significant poor prognostic factor in the Glioblastoma patients treated with radiation therapy..

2)对神经胶质细胞而言，未成熟细胞的X射线敏感性与未成熟细胞无明显差异。神经胶质细胞对X射线的敏感性略低于神经细胞。3)在抗肿瘤作用方面，加入TMZ的X射线效果是不加TMZ的1.6倍。此外，在脑移植模型中，联合应用TMZ和GYKI52466的X射线效果比单独使用TMZ高10%。对于RBE，当同时使用TMZ时，碳离子束对X射线的RBE估计约为3，与体内模型中不使用TMZ的RBE相似。此外，TMZ的组合效应是一种相加效应。4)TMZ与碳离子束联合应用不能增强放射效应。5)X射线照射后肿瘤细胞Akt和PDK1的表达增加，且与细胞运动的激活有关。在临床上，活化Akt和PDK1的强表达是胶质母细胞瘤放射治疗患者预后不良的显著因素。

项目成果

Multisession Cyberknife radiosurgery for large brain metastasis Inter. Stereotactic Radiosurgery

多节段射波刀放射外科治疗大面积脑转移瘤。

• 发表时间: 2009
• 作者: Inoue K;Nozaki A;Suzuki Y;et;al
• 通讯作者: al

Prognostic Impact of Mitotic Index Of Proliferating Cell Populations (pMI) in Cervical Cancer Patients Treated with Carbon Ion Beam. PTCOG

增殖细胞群有丝分裂指数 (pMI) 对接受碳离子束治疗的宫颈癌患者的预后影响。

• 发表时间: 2008
• 作者: Y. Suzuki;K. Oka;et;al
• 通讯作者: al

Growth Cone Collapse and Neurite Retractions: An Approach to Examine X-irradiation Affects on Neuron Cells

• DOI: 10.1269/jrr.08013
• 发表时间: 2008-09-01
• 期刊: JOURNAL OF RADIATION RESEARCH
• 影响因子: 2
• 作者: Al-Jahdari, Wael S.;Suzuki, Yoshiyuki;Nakano, Takashi
• 通讯作者: Nakano, Takashi

Carbon beam therapy overcomes hypoxia-originating radiation -resistant nature of uterine cervical cancer.

碳束疗法克服了宫颈癌因缺氧而产生的抗辐射性质。

• 发表时间: 2010
• 作者: Suzuki Y;Nakano T;Ohno T;Oka K;Suzuki Y
• 通讯作者: Suzuki Y

Effect of Irradiation on the Development of Immature Hippocampal Neurons In Vitro

体外辐射对未成熟海马神经元发育的影响

• 发表时间: 2009
• 期刊: Radiat.Res. 172
• 作者: 森勢将雅;大西壮登;河原英紀;片寄晴弘;西浦敬信;Okamoto M
• 通讯作者: Okamoto M