Molecular biological investigation about the effect of heavy-ion beam on normal brain

重离子束对正常大脑影响的分子生物学研究

• 批准号: 22791167
• 负责人: SUZUKI Yoshiyuki
• 金额: $ 2.5万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791167/
• 关键词: 炭素イオン線; 悪性脳腫瘍; 遊走能; 増感剤; ニューロン; 神経幹細胞; 放射線治療; グリア

1) Carbon-ion beams were about 10-fold more effective than X-rays in immature hippocampal neurons. X-irradiation immediately induced morphological changes in axons and dendrite. These changes seemed to be caused by x-irradiation evoking depolymerization of microfilament.2) Under severe hypoxic condition for 1 hour, oxygen enhancement ratio (OER) of X-ray was calculated as 2.7. Also, Under severe hypoxic condition for 24 hour, OER of X-ray was calculated as 2.6. OER was decreased to 1.1 by the combination use of X-ray irradiation and mTOR inhibitor. However, OER was not changed by combination use of carbon-ion beam irradiation and mTOR inhibitor.3) The RBE of C-beams to X-rays in the normal cerebellum of infant rats with rat organotypic slice culture system was assumed to be 1.4.

1)在未成熟的海马神经元中，碳离子束的效率大约是X射线的10倍。X射线照射后即刻引起轴突和树突的形态变化。这些变化可能是由于X射线照射引起微丝解聚引起的。2)在严重低氧条件下，X射线的氧增强比(OER)为2.7。此外，在严重缺氧条件下24小时，计算出X射线的OER为2.6。联合应用X射线照射和mTOR抑制剂后，OER降至1.1。然而，碳离子束照射和mTOR抑制剂的联合使用并不改变OER。3)采用大鼠器官型切片培养系统，正常幼鼠小脑对C射线的RBE假设为1.4。

项目成果

Development of head module for multi-head Si/CdTe Compton camera for medical applications

开发用于医疗应用的多头 Si/CdTe 康普顿相机的头模块

• 发表时间: 2011
• 期刊: Instr. Meth. Phys. Res.
• 作者: Yamaguchi M;Kawachi N;Suzui N;Fujimaki S;Kamiya T;Odaka H;Ishikawa S;Kokubun M;Watanabe S;Takahashi T;Shimada H;Arakawa K;Suzuki Y;Torikai K;Yoshida Y;Nakano T. Nucl
• 通讯作者: Nakano T. Nucl

The Effect Of HIF-1α On Radioresistance In Acute Hypoxia, In Vitro

HIF-1α 对急性缺氧体外放射抗性的影响

• 发表时间: 2011
• 作者: Oike T;Suzuki Y;et al.
• 通讯作者: et al.

A role of radiosurgery for functinal preservation : from personal ezperiences of 4500 patients treated wuth microsurgery, Gamma Knife and CyberKnife radiosurgery

放射外科对于功能保留的作用：来自 4500 名接受显微外科、伽玛刀和射波刀放射外科治疗的患者的个人经验

• 发表时间: 2011
• 作者: Inoue KH;Suzuki Y;Takahashi T;Sakurai H
• 通讯作者: Sakurai H

Textbook of Radiosurgery:総論5章F

放射外科教科书：通则第5F章

• 发表时间: 2012
• 作者: 白井克幸;鈴木義行
• 通讯作者: 鈴木義行

免疫細胞療法II

免疫细胞疗法II

• 发表时间: 2011
• 作者: 鈴木義行;吉本由哉
• 通讯作者: 吉本由哉