Search for new susceptibility gene controlled of cleft and/or palate development using p53 knock-out mice

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We suffer from MSM p53 knockout mouse production. We continue a study continuously and are planning to achieve a purpose. Whereas the condition establishment of p53 typing and the PCR which we used microsatellite marker for was almost decided. We aim at the stable typing by adjusting a condition sequentially.It have not lead to the identification of new susceptibility gene for cleft lip and palate promotion yet, but the identification of the applicable gene cluster, analysis of function, likelihood of the contribution to a clinical were shown in future by continuing this study.