Search for new susceptibility gene controlled of cleft and/or palate development using p53 knock-out mice

我们患有MSM p53基因敲除小鼠。我们不断地继续学习，并计划达到一个目的。而用微卫星标记进行p53分型和PCR的条件基本确定。我们的目标是通过顺序调整条件来实现稳定的类型。目前尚未鉴定出新的唇腭裂促进易感基因，但今后继续进行研究，将会发现适用基因簇的鉴定、功能分析以及对临床的贡献可能性。

We suffer from MSM p53 knockout mouse production. We continue a study continuously and are planning to achieve a purpose. Whereas the condition establishment of p53 typing and the PCR which we used microsatellite marker for was almost decided. We aim at the stable typing by adjusting a condition sequentially.It have not lead to the identification of new susceptibility gene for cleft lip and palate promotion yet, but the identification of the applicable gene cluster, analysis of function, likelihood of the contribution to a clinical were shown in future by continuing this study.