A role of insulin signal impairment in the pathogenesis of Alzheimer disease

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Insulin resistance caused by diabetes is now recognized as risk factor of Alzheimer disease (AD). We conducted a research to verify a role of insulin signal impairment in AD pathogenesis and here provide following findings. i) increase of insulin in culture medium leads to enhanced production of β-amyloid (Aβ). ii) overproduction of Aβ induces abnormal phosphorylation of tau, iii) insulin signal transduction is impaired by overproduction of Aβ. These findings suggest that heperinsulinemia may accelerates AD pathogenesis and insulin signal transduction may play a role in Aβ-induced tau phosphorylation.