Mechanisms underlying the effect of immunotherapy for anti-factor VIII inhibitor antibodies
Mechanisms underlying the effect of immunotherapy for anti-factor VIII inhibitor antibodies
批准号:
20591258
负责人:
TANAKA Ichiro
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The changes of inhibitor IgG subclasses during the course of Immune Tolerance Induction (ITI) therapy were examined. The data obtained suggested that both IgG1 and IgG4 subclasses were useful for the monitoring of therapeutic effect of ITI. Using the thrombin generation test, hemostatic effect of factor VIII in the presence of inhibitor IgG was examined. The thrombin generation pattern varied by the recognition site of inhibitor IgG. These data suggested that there might be a difference in the prophylactic effect of regular infusion of factor VIII concentrate during the ITI.
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後天性血友病における免疫応答
获得性血友病的免疫反应
DOI:
--
发表时间:
2010
期刊:
Annual Review 2010血液
影响因子:
--
作者:
[在津正文, 浜崎雄平, 古賀正啓, 土井知己, 野原薫, 佐藤忠司, 船越亜希子, 高柳俊光, 久田直樹, 小林育子, 前田寿幸, 市丸智浩, 西奈津子, 酒井菜那, 力武典子, 宮崎真穂美, 田中一郎]
通讯作者:
田中一郎
海外のガイドラインにみるインヒビター保有血友病患者に対する止血療法の現状-わが国のガイドライン作成に向けて-
海外指南中血友病抑制剂患者的止血治疗现状 -致力于制定日本指南-
DOI:
--
发表时间:
2008
期刊:
日本小児血液学会雑誌 22巻
影响因子:
--
作者:
[田中一郎, 嶋緑倫]
通讯作者:
嶋緑倫
Successful management of Mallory-Weiss syndrome in a hemophilia A patient with inhibitor by recombinant activated factor VII
通过重组激活因子 VII 成功治疗具有抑制剂的 A 型血友病患者的 Mallory-Weiss 综合征
DOI:
--
发表时间:
2008
期刊:
Haemophilia 14巻
影响因子:
--
作者:
[Uchida Y, Sakurai Y, Tanaka I, 他4名(5番目)]
通讯作者:
他4名(5番目)
血友病センタ.整備案
血友病中心改进计划
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[森尾友宏, 富澤大輔, 梶原道子, 水谷修紀, 熱田由子, 加藤剛二, 原寿郎, 加藤俊一, 田中一郎]
通讯作者:
田中一郎
インヒビター保有先天性血友病患者に対する止血治療ガイドライン
抑制物先天性血友病患者的止血治疗指南
DOI:
--
发表时间:
2008
期刊:
日本血栓止血学会誌 19
影响因子:
--
作者:
[田中一郎, 天野景裕, 瀧正志, 岡敏明, 酒井道生, 白幡聡, 高田昇, 高松純樹, 竹谷英之, 花房秀次, 日笠聡, 福武勝幸, 藤井輝久, 松下正, 三間屋純一, 吉岡章, 嶋緑倫]
通讯作者:
嶋緑倫
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THE EVOLUTION OF BLOOD COAGULATION FACTOR VIII IN MAMMALS
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