Regulation mechanism in keratinocyte growth and differentiation by p53 homologue p51/p63 and Maf

p53同源物p51/p63和Maf对角质形成细胞生长和分化的调节机制

• 批准号: 20591314
• 负责人: OKUYAMA Ryuhei
• 金额: $ 2.91万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591314/
• 关键词: 表皮細胞; p51; p63; シグナル伝達; デスモプラキン; 乾癬; p51/p63; Desmoplakin; Perp; Bach

p51/p63, a homologue of p53 tumor suppressor, is well known to play a role in oncogenesis. Simultaneously, p51/p63 promotes development of cellular characters specific for squamous cells, such as keratinocytes. Contrast to p51/p63, TGFβ suppresses these cellular characters as squamous cells, which leads to induction of cellular functions specific for mesenchymal cells. We focused on desmoplakin, calcium-dependent homophilic adhesion molecule, because the desmoplakin is a unique molecule in squamous cells. We found that desmoplakin expression is increased by p51/p63 whereas it is decreased by TGFβ.

p51/p63 是 p53 肿瘤抑制因子的同源物，众所周知在肿瘤发生中发挥作用。同时，p51/p63 促进鳞状细胞（例如角质形成细胞）特有的细胞特征的发育。与 p51/p63 相比，TGFβ 抑制鳞状细胞的这些细胞特征，从而诱导间充质细胞特异的细胞功能。我们专注于桥粒斑蛋白，钙依赖性同质粘附分子，因为桥粒斑蛋白是鳞状细胞中的独特分子。我们发现 p51/p63 增加桥粒斑蛋白的表达，而 TGFβ 则减少桥粒斑蛋白的表达。

项目成果

Cutaneous accumulation of abnormal polyglutamine proteins of patients with dentatorubral‐pallidoluysian atrophy

齿状红核-苍白路易体萎缩患者皮肤异常聚谷氨酰胺蛋白的积累

• DOI: 10.1111/j.1468-1331.2009.02658.x
• 发表时间: 2009
• 期刊: European Journal of Neurology
• 影响因子: 5.1
• 作者: M. Ohta;Ryuhei Okuyama;E. Ogawa;K. Kisu;H. Sato;Masashi Aoki;Setsuya Aiba
• 通讯作者: Setsuya Aiba

Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4

• DOI: 10.1002/dvdy.21639
• 发表时间: 2008-08-01
• 期刊: DEVELOPMENTAL DYNAMICS
• 影响因子: 2.5
• 作者: Mohri, Yasuaki;Kato, Shigeki;Nishimori, Katsuhiko
• 通讯作者: Nishimori, Katsuhiko

Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in hematologic malignancies

• DOI: 10.1038/jhg.2010.116
• 发表时间: 2010-12-01
• 期刊: JOURNAL OF HUMAN GENETICS
• 影响因子: 3.5
• 作者: Komatsuzaki, Shoko;Aoki, Yoko;Matsubara, Yoichi
• 通讯作者: Matsubara, Yoichi

Impetigo with tense bulla on the dorsal hand.

手背上有脓疱病，伴有紧张的大疱。

• 发表时间: 2010
• 期刊: J Dermatol
• 影响因子: 3.1
• 作者: Masu T;Suetake S;Alba S;Okuyama R.
• 通讯作者: Okuyama R.

TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation.

TGF-β1 抑制树突状细胞对环境刺激的敏感性，导致需要危险信号才能激活。

• 发表时间: 2009
• 期刊: Immunology
• 影响因子: 6.4
• 作者: Ohtani T;et al.
• 通讯作者: et al.