Establishment of the method to induce periodontal tissue cells for the allogenic tooth transplantation in clinical dentistry

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This study aims to clarify the responses of BrdU label-retaining cells during pulpal and periodontal healing following allogenic transplantation in mice using prenatal BrdU-labeling. As a result, it is suggested that the maintenance of BrdU-label-retaining dental pulp cells is the decisive factor for the regeneration of odontoblast-like cells in the process of pulpal healing following tooth transplantation. Tooth transplantation using GFP mice demonstrated that the donor cells constituted the dental pulp of the transplant except for endothelial cells and some migrated cells, and the periodontal tissue was replaced by host-derived cells except for epithelial cell rests of Malassez.