Proteomic analysis for mechanisms of neuropathic pain

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Chronic pain is maintained by plastic change to synapse in the spinal dorsal horn. We previously clarified that the phosphorylation of Y1472 NR2B is important for neuropathic pain. In the present study, we determined the phosphorylation cascade through activation of CaMKII and identified two molecules as changing volume of protein after SNI in the postsynaptic density fraction by proteomic analysis using Y1472F KI mice, which have a knock-in mutation of the Tyr1472 site to phenylalanine, as comparison subject.