Basic studies on high-altitude training : Chemoreceptor mechanism on spontaneously hypertensive rats(SHR) in chronic hypoxia

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The carotid bodies, which are located at the carotid bifurcation and are the primary organs for sensing changes in arterial blood gases, became significantly enlarged in spontaneously hypertensive animals(SHR). In spite of enlargement, there was no obvious vascular enlargement in SHR. SHR showed a significant increase in extracellular matrix in the carotid body. These indicate that the mechanism of carotid body enlargement in SHR is different from that in hypoxic animals. In addition, the present studies suggest facilitated noradrenaline biosynthesis in chemoreceptor cells of carotid bodies in SHR.