Structure and formation of bacterial lipid domains

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Cardiolipin and phosphatidylethanolamine are localized in the septal and polar membranes, not distributed homogeneously, in Bacillus subtilis cells. In order to clarify the structure and mechanism of formation of bacterial lipid domains, we have adopted following two approaches. (i) To examine the distribution of other membrane lipids, we have screened a library of oligopeptides with random amino acid sequence to develop new probes for specific detection of the other lipids. (ii) To study the mechanism of lipid domain formation, the means to localize septally of lipid synthases and MinD, which regulates the position of cell division, is examined with special focus on the region at its COOH-terminus.