Isolation and functional expression of novel putative carbon dioxide(CO_2) receptors in respiratory epithelium.

小鼠鼻上皮细胞部分表现出co_2诱导的细胞内钙动员。这些细胞对激活质子敏感阳离子通道的配体没有反应，如瞬时受体电位香草素1（TRPV1）、酸感离子通道（ASIC） 1a、ASIC1b、ASIC2a、ASIC2b和ASIC3。由于鼻上皮细胞对NaHCO_3溶液而非酸性pH溶液有应答，因此hco_3的检测机制可能与鼻腔CO_2感知有关。

Mouse nasal epithelial cells partially exhibited CO_2-induced intracellular calcium mobilization. These cells did not respond to the ligands that activate proton-sensitive cation channels, such as transient receptor potential vanilloid 1(TRPV1), acid-sensing ion channel(ASIC) 1a, ASIC1b, ASIC2a, ASIC2b and ASIC3.Since the nasal epithelial cells responded to NaHCO_3 solution rather than acidic pH solution, a mechanism for detection of HCO_3-may be involved in nasal CO_2 perception.