The Regulation and Pathophysiology of Intracellular Water Metabolism by an Intracellular Aquaporin

本研究揭示了内质网（ER）应激反应的重要性，诱导的积累的展开蛋白在ER的AQP11基因敲除小鼠的多囊肾的发展，通过全面的基因和蛋白表达的肾脏调查。除肾脏外，AQP11还在肝脏、睾丸、胸腺和大脑中发挥作用。值得注意的是，AQP11在脑毛细血管内皮表达，似乎是为了适应脑中的渗透应激。

This study revealed the importance of endoplasmic reticulum(ER) stress reaction induced by the accumulation of unfold proteins in the ER for the development of polycystic kidneys in AQP11 null mice by comprehensive gene and protein expression surveys of the kidney. Other than the kidney, AQP11 plays some roles in the liver, testis, thymus and brain. It is noteworthy that AQP11 is expressed at the endothelium of cerebral capillaries seemingly for the adaptation of osmotic stresses in the brain.