The function of mitochondrial CYP1A1 in the lipid metabolism.

线粒体 CYP1A1 在脂质代谢中的功能。

• 批准号: 21590319
• 负责人: UNO Shigeyuki
• 金额: $ 3万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590319/
• 关键词: 生体分子医学; チトクロームP450; ミトコンドリア; 生体異物代謝; 脂質代謝

To understand the physiological functions of polycyclic aromatic hydrocarbons(PHAs) induced microsomal versus mitochondrial CYP1A1, it is the microsomal rather than mitochondrial CYP1A1 enzyme that protects against oral BaP toxicity. Because of metabolic delay of PHAs causes abnormal expression of transporter genes, PHAs is induced abnormal lipid metabolism. Our data support the likelihood that it is the microsomal rather than mitochondrial CYP1A1 enzyme that protects against PHAs induced mitochondrial dysfunction.

为了了解多环芳烃（PHAs）诱导的微粒体与线粒体CYP1A1的生理功能，它是微粒体而不是线粒体CYP1A1酶，保护免受口服BaP毒性。由于PHAs的代谢延迟导致转运体基因的异常表达，PHAs引起脂质代谢异常。我们的数据支持这样一种可能性，即是微粒体而不是线粒体CYP1A1酶防止pha诱导的线粒体功能障碍。

项目成果

Knock-in mouse lines expressing either mitochondria or microsomal CYP1A 1 : differing responses to dietary benzo[a]pyrene as proof of principle

表达线粒体或微粒体 CYP1A 1 的敲入小鼠系：对膳食苯并[a]芘的不同反应作为原理证明

• 发表时间: 2009
• 期刊: Molecular Pharmacology 75
• 作者: Dong H;Dalton TP;Miller ML;Chen Y;Uno S;Shi Z;Shertzer HG;Bansal S;Avadhani NG;Nebert DW;Hongbin Dong
• 通讯作者: Hongbin Dong