Diversified studies on the genetic background of high-grade malignant thyroid tumors

我们对甲状腺癌的遗传背景进行了多样化的研究，发现了一些有趣的发现：1)BRAF基因的点突变在高分化甲状腺癌向未分化甲状腺癌的进展机制中发挥了重要作用。2)我们的研究表明，RET基因重排和/或PPARγ/ pax8对未分化进展并不重要。3)有趣的是，水通道蛋白4可能与滤泡细胞源性甲状腺肿瘤有关，而在未分化甲状腺癌中不表达。综上所述，这些发现对了解甲状腺癌的病理和分子治疗具有重要意义。

We have performed diversified studies on the genetic background of thyroid cancers and found some interesting findings as follows1) The point mutation of BRAF gene can play an important role in the progression mechanism from well differentiated thyroid cancer to undifferentiated thyroid cancer.2) Our studies revealed that RET gene rearrangements and/or PPARγ/PAX8is not important for the undifferentiated progression.3) It was interesting that aquaporin 4 can be related to follicular cell derived thyroid tumors and not expressed in undifferentiated thyroid carcinoma.In conclusion, these findings described above can be important for understanding thyroid cancer pathology and molecular therapies.