Molecular mechanism of pathogenic chlamydial infection to lymphocytes

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We assessed pathogenic chlamydial infection mechanism to lymphocytes when compared to epithelial cells. As a result, we found the unique chlamydial attachment process on lymphocytes, independent of heparin, which has a critical on bacterial general attachment to cells. It was also confirmed by using DNA microarray that pathogenic chlamydial survival in lymphocytes was controlled by granzyme K. Furthermore, we demonstrated that lymphocytes could provide a shelter for pathogenic chlamydiae to escape from IFNγ. Thus, pathogenic chlamydial infection mechanism to lymphocytes is unique when compared to epithelial cells, possibly connecting clinical significance.