Molecular mechanism of pathogenic chlamydial infection to lymphocytes

与上皮细胞相比，我们评估了致病性衣原体感染淋巴细胞的机制。结果，我们发现了独特的衣原体在淋巴细胞上的附着过程，独立于肝素，这对细菌对细胞的一般附着具有关键作用。通过DNA微阵列技术证实，致病性衣原体在淋巴细胞中的存活受颗粒酶k的控制。此外，我们还证明淋巴细胞可以为致病性衣原体提供逃避IFNγ的庇护所。因此，与上皮细胞相比，致病性衣原体感染淋巴细胞的机制是独特的，可能具有临床意义。

We assessed pathogenic chlamydial infection mechanism to lymphocytes when compared to epithelial cells. As a result, we found the unique chlamydial attachment process on lymphocytes, independent of heparin, which has a critical on bacterial general attachment to cells. It was also confirmed by using DNA microarray that pathogenic chlamydial survival in lymphocytes was controlled by granzyme K. Furthermore, we demonstrated that lymphocytes could provide a shelter for pathogenic chlamydiae to escape from IFNγ. Thus, pathogenic chlamydial infection mechanism to lymphocytes is unique when compared to epithelial cells, possibly connecting clinical significance.