Development of a new endoscopic therapy using RNAi for intestinal fibrosis of Crohn's disease

开发利用RNAi治疗克罗恩病肠纤维化的新内窥镜疗法

• 批准号: 21590807
• 负责人: SUZUKI Kenji
• 金额: $ 3万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590807/
• 关键词: 炎症性腸疾患; クローン病; 線維化; siRNA; RNAi; 内視鏡; 糖鎖; 消化管狭窄; RNA干渉; 内視鏡的治療

We have developed a new siRNA medicine, STNM-01 with Stelic Institute. In this project, we studied the therapeutic effects and the mechanism of endoscopic submucosal injection of the STNM-01 for the treatment of intestinal fibrosis using animal models. We have successfully developed a novel endoscopic injection therapy of STNM-01 for the treatment of intestinal fibrosis of Crohn's disease. Using this technique, we have started a phase I clinical trial for patients with Crohn's disease in Japan since January, 2012.

我们与Stelic Institute合作开发了一种新的siRNA药物STNM-01。在本课题中，我们通过动物模型研究了STNM-01对肠纤维化的治疗作用及其机制。我们已经成功地开发出一种新的STNM-01内窥镜注射疗法，用于治疗克罗恩病的肠纤维化。使用这项技术，自2012年1月以来，我们已经在日本启动了针对克罗恩病患者的I期临床试验。

项目成果

Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function I streptozocin-induced diabetic rats

血管紧张素受体阻滞剂对链佐星糖尿病大鼠氧化应激及心肾功能的影响

• 发表时间: 2009
• 期刊: Biol.Pharm. Bull 32
• 作者: Wawaimuli Arozat;et al.
• 通讯作者: et al.

A detailed investigation of accessibilities around target sites of siRNAs and miRNAs

• DOI: 10.1093/bioinformatics/btr276
• 发表时间: 2011-07-01
• 期刊: BIOINFORMATICS
• 影响因子: 5.8
• 作者: Kiryu, Hisanori;Terai, Goro;Asai, Kiyoshi
• 通讯作者: Asai, Kiyoshi

Beneficial effects of angiotensin II receptor blocker, olmesartan, in limiting the cardiotoxic effect of daunorubicin in rats

• DOI: 10.3109/10715762.2010.509399
• 发表时间: 2010-11-01
• 期刊: FREE RADICAL RESEARCH
• 影响因子: 3.3
• 作者: Arozal, Wawaimuli;Watanabe, Kenichi;Aizawa, Yoshifusa
• 通讯作者: Aizawa, Yoshifusa

Carvedilol attenuates inflammatory-medicated cardiotoxicity in Daunorubicin-induced rats.

卡维地洛可减轻柔红霉素诱导的大鼠炎症引起的心脏毒性。

• 发表时间: 2011
• 期刊: Pharmaceuticals
• 影响因子: 4.6
• 作者: Okamoto R;Tsuchiya K;Nemoto Y;Akiyama J;Nakamura T;Kanai T;Watanabe M;Flori R Sari
• 通讯作者: Flori R Sari

Beneficial effects of olmesartan, angiotensin II receptor type 1 antagonist, in rats with dilated cardiomyopathy.

奥美沙坦（1 型血管紧张素 II 受体拮抗剂）对扩张型心肌病大鼠的有益作用。

• 发表时间: 2010
• 期刊: Experimental Biology and Medicine
• 影响因子: 3.2
• 作者: Sugimoto M;Osawa S;Sugimoto K;et al. (計 7 人);Vijayakumar Sukumaran
• 通讯作者: Vijayakumar Sukumaran