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Development of a new endoscopic therapy using RNAi for intestinal fibrosis of Crohn's disease

Development of a new endoscopic therapy using RNAi for intestinal fibrosis of Crohn's disease
开发利用RNAi治疗克罗恩病肠纤维化的新内窥镜疗法
批准号:
21590807
负责人:
SUZUKI Kenji
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
We have developed a new siRNA medicine, STNM-01 with Stelic Institute. In this project, we studied the therapeutic effects and the mechanism of endoscopic submucosal injection of the STNM-01 for the treatment of intestinal fibrosis using animal models. We have successfully developed a novel endoscopic injection therapy of STNM-01 for the treatment of intestinal fibrosis of Crohn's disease. Using this technique, we have started a phase I clinical trial for patients with Crohn's disease in Japan since January, 2012.
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会议论文
Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function I streptozocin-induced diabetic rats
血管紧张素受体阻滞剂对链佐星糖尿病大鼠氧化应激及心肾功能的影响
DOI: --
发表时间: 2009
期刊: Biol.Pharm. Bull 32
影响因子: --
作者: [Wawaimuli Arozat, et al.]
通讯作者: et al.
DOI: 10.1093/bioinformatics/btr276
发表时间: 2011-07-01
期刊: BIOINFORMATICS
影响因子: 5.8
作者: [Kiryu, Hisanori, Terai, Goro, Asai, Kiyoshi]
通讯作者: Asai, Kiyoshi
DOI: 10.3109/10715762.2010.509399
发表时间: 2010-11-01
期刊: FREE RADICAL RESEARCH
影响因子: 3.3
作者: [Arozal, Wawaimuli, Watanabe, Kenichi, Aizawa, Yoshifusa]
通讯作者: Aizawa, Yoshifusa
Carvedilol attenuates inflammatory-medicated cardiotoxicity in Daunorubicin-induced rats.
卡维地洛可减轻柔红霉素诱导的大鼠炎症引起的心脏毒性。
DOI: --
发表时间: 2011
期刊: Pharmaceuticals
影响因子: 4.6
作者: [Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M, Flori R Sari]
通讯作者: Flori R Sari
20
    Foundation of Soft Robotic Assistive Technologies for Supporting Voluntary Postural Transitions
    • 批准号:
      26289058
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.73万
    • 财政年份:
      2014
    • 负责人:
      SUZUKI Kenji
    • 依托单位:
    Challenge to evaluation of internal stress for materials with coarse grains
    • 批准号:
      24656083
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      SUZUKI Kenji
    • 依托单位:
    Treatment of intestinal fibrosis of Crohn disease by regulation of expression of glycan chains
    • 批准号:
      24590938
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.49万
    • 财政年份:
      2012
    • 负责人:
      SUZUKI Kenji
    • 依托单位:
    Exhaustive analysis of the antitumor effect by suppression of vascularization that is a function of chemokine BRAK
    • 批准号:
      23792156
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.66万
    • 财政年份:
      2011
    • 负责人:
      SUZUKI Kenji
    • 依托单位:
    海外基金