Development of a new endoscopic therapy using RNAi for intestinal fibrosis of Crohn's disease
Development of a new endoscopic therapy using RNAi for intestinal fibrosis of Crohn's disease
批准号:
21590807
负责人:
SUZUKI Kenji
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We have developed a new siRNA medicine, STNM-01 with Stelic Institute. In this project, we studied the therapeutic effects and the mechanism of endoscopic submucosal injection of the STNM-01 for the treatment of intestinal fibrosis using animal models. We have successfully developed a novel endoscopic injection therapy of STNM-01 for the treatment of intestinal fibrosis of Crohn's disease. Using this technique, we have started a phase I clinical trial for patients with Crohn's disease in Japan since January, 2012.
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Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function I streptozocin-induced diabetic rats
血管紧张素受体阻滞剂对链佐星糖尿病大鼠氧化应激及心肾功能的影响
DOI:
--
发表时间:
2009
期刊:
Biol.Pharm. Bull 32
影响因子:
--
作者:
[Wawaimuli Arozat, et al.]
通讯作者:
et al.
DOI:
10.1093/bioinformatics/btr276
发表时间:
2011-07-01
期刊:
BIOINFORMATICS
影响因子:
5.8
作者:
[Kiryu, Hisanori, Terai, Goro, Asai, Kiyoshi]
通讯作者:
Asai, Kiyoshi
DOI:
10.3109/10715762.2010.509399
发表时间:
2010-11-01
期刊:
FREE RADICAL RESEARCH
影响因子:
3.3
作者:
[Arozal, Wawaimuli, Watanabe, Kenichi, Aizawa, Yoshifusa]
通讯作者:
Aizawa, Yoshifusa
Carvedilol attenuates inflammatory-medicated cardiotoxicity in Daunorubicin-induced rats.
卡维地洛可减轻柔红霉素诱导的大鼠炎症引起的心脏毒性。
DOI:
--
发表时间:
2011
期刊:
Pharmaceuticals
影响因子:
4.6
作者:
[Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M, Flori R Sari]
通讯作者:
Flori R Sari
Beneficial effects of olmesartan, angiotensin II receptor type 1 antagonist, in rats with dilated cardiomyopathy.
奥美沙坦(1 型血管紧张素 II 受体拮抗剂)对扩张型心肌病大鼠的有益作用。
DOI:
--
发表时间:
2010
期刊:
Experimental Biology and Medicine
影响因子:
3.2
作者:
[Sugimoto M, Osawa S, Sugimoto K, et al. (計 7 人), Vijayakumar Sukumaran]
通讯作者:
Vijayakumar Sukumaran
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Challenge to evaluation of internal stress for materials with coarse grains
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Facial Expression Reading for Describing and Augmenting Interaction
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Position-controlled fixation of oligonucleotides on nanoparticlesurfaces using DNA nanostructures as templates
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Study on manipulation of micro objects using surface tension of liquid droplets
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Evaluation of Local Air Movement on Skin Temperature and Thermal Sensation by Corrected Humid Operative Temperature
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Insect-Based Nano and Micro Composite Systems with Structured Surfaces
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the role of adaptor protein SH2-B in adipocyte differentiation
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ROLE OF BRCA1 IN RADIATION-INDUCED CENTROSOMAL CHECKPOINT
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Strength Estimation and Residual Stress Analysis of Thermal Barrier Coatings by Synchrotron Radiations.
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TRIBOLOGICAL DESIGN FOR MICRO SLIDING BEARINGS
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Nano-Structure of Amorphous and Cluster-Assembled Materials
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A CULTURAL STUDY ON AMERICAN HISTRICAL MATERIALS
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Measurment and estimation of residual stress distribution in thim films and coatings
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海外基金