Exhaustive analysis of the antitumor effect by suppression of vascularization that is a function of chemokine BRAK

详尽分析趋化因子 BRAK 所发挥的抑制血管化作用的抗肿瘤作用

• 批准号: 23792156
• 负责人: SUZUKI Kenji
• 金额: $ 2.66万
• 依托单位: Kanagawa Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792156/
• 关键词: ケモカイン CXCL14/BRAK; 免疫沈降法; HUVEC の細胞増殖能; DIVAA システム; ケモカインCXCL14/BRAK; HUVECの細胞増殖能; DIVAAシステム; ケモカイン

Human needs oxygen and nourishment to live , and the blood vessel plays an important role that carries and absorbs oxygen and nourishment. Cancer is the same, and it is thought that cancer grow while forming blood vessel actively. In other words, prevention of the formation of blood vessel carrying oxygen and nourishment may stop the growth of cancer. The study group of us already discovered the protein which suppresses the growth of cancer, and it is clarified that the relations of the proteinand forming blood vessel in this study.

人类的生存需要氧气和营养，而血管对氧气和营养的输送和吸收起着重要的作用。癌症也是一样，人们认为癌症在生长的同时活跃地形成了血管。换句话说，防止携带氧气和营养的血管的形成可能会阻止癌症的生长。我们课题组已经发现了抑制肿瘤生长的蛋白质，并在本研究中阐明了该蛋白质与血管形成的关系。

项目成果

Reactive oxygen species reduce the production of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells.

活性氧可减少人头颈鳞状细胞癌细胞中 BRAK/CXCL14 的产生。

• 发表时间: 2009
• 作者: MIYAMOTO C.;MAEHATA Y.;YOSHINO F.;KOBAYASHI K.;LEE M.C.-I.
• 通讯作者: LEE M.C.-I.

Calcium-calmodulin signaling induced by epithelial cell differentiation upregulates BRAK/CXCL14 expression via the binding of SP1 to the BRAK promoter region

• DOI: 10.1016/j.bbrc.2012.01.157
• 发表时间: 2012-04-06
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Ikoma, Takeharu;Ozawa, Shigeyuki;Kubota, Eiro
• 通讯作者: Kubota, Eiro

変異したP53による抗腫瘍性ケモカインBRAKの発現調節

突变 P53 对抗肿瘤趋化因子 BRAK 表达的调节

• 发表时间: 2012
• 作者: 鬼頭慎司，小田昌史，田中達朗;志岐一欣，松本（武田）忍，大塚 梢;林 祐樹;滝野正義;若杉（佐藤）奈緒;廣松辰巳;森本泰宏：;小澤重幸
• 通讯作者: 小澤重幸