Functional analysis of parafibromin with activities of tumor suppressor and oncogene

具有抑癌基因和癌基因活性的副纤维蛋白的功能分析

• 批准号: 21591180
• 负责人: YOSHIMOTO Katsuhiko
• 金额: $ 2.91万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591180/
• 关键词: がん遺伝子; がん抑制遺伝子; 副甲状腺腫瘍; 内科; 内分泌; 腫瘍; 副甲状腺; miRNA; 癌遺伝子; 癌抑制遺伝子

We found a germ-line mutation(p. E29X) of the HRPT2 gene in one of three familial hyperparathyroidism families. We found reduced expression of U6 by over-expression of the HRPT2 gene. U6 is a small non-coding RNA and transcribed by RNA polymerase III. U6 is involved in splicing of mRNA, over-expressed in many tumors, and positively regulates cell growth. These results suggested that U6 might play an important role of regulation of parafibromin-related cell growth.

我们在三个家族性甲状旁腺功能亢进症家族中的一个中发现了HRPT2基因的种系突变（p.E29X）。我们发现HRPT2基因的过度表达降低了U6的表达。U6是一种小的非编码RNA，由RNA聚合酶III转录。U6参与mRNA的剪接，在许多肿瘤中过表达，并正调控细胞生长。这些结果提示U6可能在调节副纤蛋白相关细胞生长中起重要作用。

项目成果

Characterization of estrogen receptor beta1in human pituitary adenomas

人垂体腺瘤中雌激素受体β1的表征

• 发表时间: 2010
• 作者: ZR Qian;EL Wang;K Yoshimoto;S Yamada;T Sano
• 通讯作者: T Sano

Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families.

• DOI: 10.1002/humu.21292
• 发表时间: 2010-08
• 期刊: HUMAN MUTATION
• 影响因子: 3.9
• 作者: Igreja, Susana;Chahal, Harvinder S.;King, Peter;Bolger, Graeme B.;Srirangalingam, Umasuthan;Guasti, Leonardo;Chapple, J. Paul;Trivellin, Giampaolo;Gueorguiev, Maria;Guegan, Katie;Stals, Karen;Khoo, Bernard;Kumar, Ajith V.;Ellard, Sian;Grossman, Ashley B.;Korbonits, Marta
• 通讯作者: Korbonits, Marta

下垂体性腺腫のER1、2の発現とDNAのHYPERMETHYLATIONおよび機能分析について

ER1和2在垂体腺瘤中的表达和高甲基化及DNA功能分析

• 发表时间: 2010
• 作者: 銭志栄;王路;吉本勝彦;山田正三;佐野壽昭
• 通讯作者: 佐野壽昭

MicroRNA Expression Abnormalities in Pituitary Adenomas are Associated with Dis tinctive Pathologic Features and May Contribute to Tumorigenesis

垂体腺瘤中的 MicroRNA 表达异常与独特的病理特征相关，并可能导致肿瘤发生

• 发表时间: 2009
• 作者: Q ian Zhi Rong;Tanahashi Toshihito;Yoshimoto Katsuhiko;Yamada Shozo;Katsuura Sakurako;Rokutan Kazuhito;Sano Toshiaki
• 通讯作者: Sano Toshiaki

YKL-40 secreted from adipose tissue inhibits degradation of type I collagen

• DOI: 10.1016/j.bbrc.2009.08.024
• 发表时间: 2009-10-23
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Iwata, Takeo;Kuwajima, Masamichi;Yoshimoto, Katsuhiko
• 通讯作者: Yoshimoto, Katsuhiko