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Functional analysis of parafibromin with activities of tumor suppressor and oncogene

Functional analysis of parafibromin with activities of tumor suppressor and oncogene
具有抑癌基因和癌基因活性的副纤维蛋白的功能分析
批准号:
21591180
负责人:
YOSHIMOTO Katsuhiko
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
We found a germ-line mutation(p. E29X) of the HRPT2 gene in one of three familial hyperparathyroidism families. We found reduced expression of U6 by over-expression of the HRPT2 gene. U6 is a small non-coding RNA and transcribed by RNA polymerase III. U6 is involved in splicing of mRNA, over-expressed in many tumors, and positively regulates cell growth. These results suggested that U6 might play an important role of regulation of parafibromin-related cell growth.
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会议论文
Characterization of estrogen receptor beta1in human pituitary adenomas
人垂体腺瘤中雌激素受体β1的表征
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [ZR Qian, EL Wang, K Yoshimoto, S Yamada, T Sano]
通讯作者: T Sano
DOI: 10.1002/humu.21292
发表时间: 2010-08
期刊: HUMAN MUTATION
影响因子: 3.9
作者: [Igreja, Susana, Chahal, Harvinder S., King, Peter, Bolger, Graeme B., Srirangalingam, Umasuthan, Guasti, Leonardo, Chapple, J. Paul, Trivellin, Giampaolo, Gueorguiev, Maria, Guegan, Katie, Stals, Karen, Khoo, Bernard, Kumar, Ajith V., Ellard, Sian, Grossman, Ashley B., Korbonits, Marta]
通讯作者: Korbonits, Marta
下垂体性腺腫のER1、2の発現とDNAのHYPERMETHYLATIONおよび機能分析について
ER1和2在垂体腺瘤中的表达和高甲基化及DNA功能分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [銭志栄, 王路, 吉本勝彦, 山田正三, 佐野壽昭]
通讯作者: 佐野壽昭
MicroRNA Expression Abnormalities in Pituitary Adenomas are Associated with Dis tinctive Pathologic Features and May Contribute to Tumorigenesis
垂体腺瘤中的 MicroRNA 表达异常与独特的病理特征相关,并可能导致肿瘤发生
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Q ian Zhi Rong, Tanahashi Toshihito, Yoshimoto Katsuhiko, Yamada Shozo, Katsuura Sakurako, Rokutan Kazuhito, Sano Toshiaki]
通讯作者: Sano Toshiaki
20
    Regulation of miRNAs located within the imprinted DLK1-DIO3 locus at 14q32 in pituitary adenomas
    • 批准号:
      15K09435
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.08万
    • 财政年份:
      2015
    • 负责人:
      YOSHIMOTO Katsuhiko
    • 依托单位:
    Network of microRNA in pituitary adenomas
    • 批准号:
      24591365
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      YOSHIMOTO Katsuhiko
    • 依托单位:
    Role of the AIP gene in tumorigenesis of growth hormone-producing cells
    • 批准号:
      19591079
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      YOSHIMOTO Katsuhiko
    • 依托单位:
    Function of parafibromin inhibiting parathyroid tumorigenesis
    • 批准号:
      17590963
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2005
    • 负责人:
      YOSHIMOTO Katsuhiko
    • 依托单位:
    海外基金