Involvement of selectins and their ligands in wound healing
Involvement of selectins and their ligands in wound healing
批准号:
21591469
负责人:
SATO Shinichi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
细胞黏附分子通过白细胞募集对伤口愈合起关键作用。为了阐明细胞黏附分子P-选择素糖蛋白配体-1(PSGL-1)在创伤愈合中的作用,我们研究了PSGL-1缺陷小鼠的皮肤创伤愈合。结果提示,PSGL-1主要作为P-选择素配体促进创面愈合,部分作为E-选择素配体通过介导炎性细胞的渗透促进创面愈合。
英文摘要
Cell adhesion molecules are critical to wound healing through leukocyte recruitment. To clarify a role of P-selectin glycoprotein ligand-1(PSGL-1), one of cell adhesion molecules, in wound healing, we investigated cutaneous wound healing in PSGL-1-deficient mice. The results suggest that PSGL-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand by mediating infiltration of inflammatory cells.
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