Involvement of selectins and their ligands in wound healing

选择素及其配体参与伤口愈合

• 批准号: 21591469
• 负责人: SATO Shinichi
• 金额: $ 2.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591469/
• 关键词: 細胞接着分子; PSGL-1; P-selectin; 創傷治癒; 皮膚免疫学

Cell adhesion molecules are critical to wound healing through leukocyte recruitment. To clarify a role of P-selectin glycoprotein ligand-1(PSGL-1), one of cell adhesion molecules, in wound healing, we investigated cutaneous wound healing in PSGL-1-deficient mice. The results suggest that PSGL-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand by mediating infiltration of inflammatory cells.

细胞粘附分子通过白细胞募集对伤口愈合至关重要。为了阐明细胞粘附分子之一P-选择素糖蛋白配体-1（PSGL-1）在伤口愈合中的作用，我们研究了PSGL-1缺陷小鼠的皮肤伤口愈合。结果表明，PSGL-1主要作为P-选择素配体和部分作为E-选择素配体通过介导炎性细胞的浸润来促进伤口愈合。