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Prediction of radiosensitivity using phosphorylation of histone H2AX in human tumor cell lines

Prediction of radiosensitivity using phosphorylation of histone H2AX in human tumor cell lines
利用人类肿瘤细胞系中组蛋白 H2AX 的磷酸化预测放射敏感性
批准号:
21591608
负责人:
SASAI Keisuke
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
To develop a new predictive assay for radiosensitivity, we tested the relationship between cell survival and expression of phosphorylation of histone H2AX(γH2AX) foci using 7 different human cell lines. There was not a good correlation between the γH2AX foci frequency and surviving fraction after irradiation. When we normalized theγH2AX foci frequency by DNA content, and introduced the frequency of apoptosis to the analysis, there was a good correlation between the cell survival and the combined frequency of apoptosis and γH2AX foci in 6 cell lines except for one.
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DOI: --
发表时间: 2011
期刊: Int J Clin Oncol.
影响因子: --
作者: [Sakamoto M, Mizowaki T, Mitsumori M, Takayama K, Sasai K, Norihisa Y, Kamoto T, Nakamura E, Ogawa O, Hiraoka M]
通讯作者: Hiraoka M
DOI: --
发表时间: 2010
期刊: Int J Clin Oncol
影响因子: 3.3
作者: [Kawaguchi G, Abe E, Sasamoto R, Sasai K.]
通讯作者: Sasai K.
Full-dose capecitabine with loradiotherapy : one of the treatment options for inoperable T4 breast cancer
全剂量卡培他滨联合劳放射治疗:无法手术的 T4 乳腺癌的治疗选择之一
DOI: --
发表时间: 2011
期刊: Jpn J Radiol. 2
影响因子: --
作者: [Hirowatari H, Karasawa K, Izawa H, Ito K, Sasai K, Furuya T, Ozawa S, Arakawa A, Orihata G, Saito M.]
通讯作者: Saito M.
Effect of dose fractionation on pulmonary complications during total body irradiation
剂量分割对全身照射期间肺部并发症的影响
DOI: --
发表时间: 2011
期刊: J Radiat Resarch
影响因子: --
作者: [Izawa H, Hirowatari H, Yahata Y, Hamano Y, Ito K, Saito AI, Yamamoto H, Miura K, Karasawa K, Sasai K.]
通讯作者: Sasai K.
9
    Development of a method of prediction for tumor cell radiosensitivity using Premature Chromosome Condensation
    • 批准号:
      19591454
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.75万
    • 财政年份:
      2007
    • 负责人:
      SASAI Keisuke
    • 依托单位:
    Development of a Predictive Assay for Radiosensitivity of Esophageal and Head and Neck Cancers and Modification of the Sensitivity Using Anti-c-erbB 2 Compounds
    • 批准号:
      16390335
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $4.74万
    • 财政年份:
      2004
    • 负责人:
      SASAI Keisuke
    • 依托单位:
    Development of a predictive assay for radiosensitivity of esophageal cancer
    • 批准号:
      14570878
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2002
    • 负责人:
      SASAI Keisuke
    • 依托单位:
    Role of p53 status in combination effect of chemotherapeutic agents and radiation
    • 批准号:
      09470199
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $4.03万
    • 财政年份:
      1997
    • 负责人:
      SASAI Keisuke
    • 依托单位:
    海外基金