Amelioration of lymphedema by extracorporeal low-energy shock wave therapy through promotion of lymphangiogenesis

体外低能量冲击波疗法通过促进淋巴管生成改善淋巴水肿

• 批准号: 21591639
• 负责人: SHIRASAWA Bungo
• 金额: $ 2.83万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591639/
• 关键词: リンパ浮腫; リンパ管新生; 衝撃波; VEGF-C; VEGFR3; リンパ管; 再生医療; リンパ管再生

Lymphedema is a common complication after surgical and radiation therapy for cancer, and therapeutic options for lymphedema are currently limited and largely ineffective. The purpose of this study was to develop the method of reducing lymphedema by extracorporeal low-energy shock wave, based on the induction of lymphangiogenesis. This study shows that extracorporeal low-energy shock wave therapy ameliorates lymphedema by enhancing the expression of VEGF-C and increasing the formation of lymphatic vessels, suggesting that extracorporeal shock wave therapy may be an effective and safe method for lymphedema.

淋巴水肿是癌症手术和放射治疗后的常见并发症，目前淋巴水肿的治疗选择有限且基本上无效。本研究的目的是开发基于诱导淋巴管生成的体外低能量冲击波减轻淋巴水肿的方法。本研究表明体外低能量冲击波疗法通过增强VEGF-C的表达和增加淋巴管的形成来改善淋巴水肿，提示体外冲击波疗法可能是一种有效且安全的治疗淋巴水肿的方法。

项目成果

低出力衝撃波照射によるリンパ管再生に基づいたリンパ浮腫治療法の開発

开发基于低功率冲击波照射淋巴管再生的淋巴水肿治疗方法

• 发表时间: 2011
• 作者: 久保正幸;李桃生;鴨田隆弘;大島真子;白澤文吾;濱野公一
• 通讯作者: 濱野公一

Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis

• DOI: 10.1016/j.jvs.2010.03.017
• 发表时间: 2010-08-01
• 期刊: JOURNAL OF VASCULAR SURGERY
• 影响因子: 4.3
• 作者: Kubo, Masayuki;Li, Tao-Sheng;Hamano, Kimikazu
• 通讯作者: Hamano, Kimikazu