Amelioration of lymphedema by extracorporeal low-energy shock wave therapy through promotion of lymphangiogenesis

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Lymphedema is a common complication after surgical and radiation therapy for cancer, and therapeutic options for lymphedema are currently limited and largely ineffective. The purpose of this study was to develop the method of reducing lymphedema by extracorporeal low-energy shock wave, based on the induction of lymphangiogenesis. This study shows that extracorporeal low-energy shock wave therapy ameliorates lymphedema by enhancing the expression of VEGF-C and increasing the formation of lymphatic vessels, suggesting that extracorporeal shock wave therapy may be an effective and safe method for lymphedema.