Protective effects of yellow intraocular lens implantation on light-induced photoreceptor damage in mice

采用新型小鼠人工晶状体植入术模型，研究了有色人工晶状体对光致视网膜光毒性的保护作用。采用类似人类白内障手术的方法，对BALB/c小鼠进行囊外晶状体摘除和人工晶体植入术。与透明iol植入的动物相比，黄色iol植入的动物在光照射下凋亡细胞数量和外视网膜厚度明显减少。视网膜电图显示，与透明IOL相比，黄色IOL可防止a波和b波振幅的下降。我们证明了彩色人工晶状体对白内障术后视网膜光毒性的保护作用。

Using a novel murine intraocular lens(IOL) implantation model, we studied the protective effects of colored-IOLs against light-induced retinal photo toxicity. Extra-capsular crystalline lens extraction and IOL implantation were performed in BALB/c mice by a technique similar to human cataract surgery. In contrast to the clear IOL-implanted animals, the yellow IOL-implanted animals had significantly reduced numbers of apoptotic cells and retained thickness of the outer retina, induced by light exposure. Electroretinography showed that yellow IOL implantation prevented a decrease of amplitude in both the a-wave and b-wave compared with clear IOL implantation. We demonstrated the protective effects of colored-IOL against retinal phototoxicity after cataract surgery.