Influence of experimental stimulation to nucleus and viscus on Sleep Bruxism

本研究的目的是实验性诱导或减少睡眠磨牙症。健康成人食管内灌注5ml酸性溶液后，SB发作频率显著升高。然后用多导睡眠图、心率变异性频率分析和血激素水平检测SB患者和健康人。大多数SB发作发生在浅非快速眼动睡眠时的交感神经支配下，伴有微觉醒。SB患者表现为交感优势睡眠质量低，应激相关激素水平高。此外，还提示通过中枢神经给药可明显减少SB发作。

The purpose of this study is experimental induction or reduction of the sleep bruxism(SB). The frequencies of SB episodes were significantly induced after intra esophageal infusion with 5 ml acidic solution in healthy adults. Then, polysomnogram, the frequency analysis of heart rate variability and blood hormone level were examined in SB patients and healthy subjects. Most SB episodes were observed under a sympathetic dominance at light non-REM sleep with the micro-arousals. The SB patients showed low quality of sleep at sympathetic predominance and high level of stress related hormone. Also, it was suggested that the SB episodes were significantly reduced through central nerve by a medication.