Impaired pain processing in Parkinson's disease and its relative association with the non-motor symptom

帕金森病的疼痛处理受损及其与非运动症状的相关性

• 批准号: 21600003
• 负责人: HIRAYAMA Masaaki
• 金额: $ 3万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21600003/
• 关键词: Parkinson's disease; pain; non-motor; dementia; somatosensory evoked potencial; olfactory function; 痛み認知; パーキンソン病; 非運動症状; 事象関連電位; 嗅覚機能; 体性感覚誘発電位; 痛み閾値; 嗅覚検査; 認知検査

Background and purpose : Many non-motor symptoms are associated with Parkinson's disease(PD). Of these, pain and olfactory disturbance tend to be common premotor symptoms. PD has been shown to exhibit abnormal central pain processing, although underlying mechanisms are not yet fully understood. In order to investigate this further, we assessed PD patients by specific Aδstimulation with intra-epidermal needle electrode and determined olfactory function.Methods : Forty-two patients(18 males and 24 females) with PD and 11 healthy control subjects(8 males and 3 females) were studied. A thin needle electrode was used to stimulate epidermal Aδfibers, and somatosensory evoked potentials(SEPs) recorded at the vertex. Olfactory function was evaluated using the Odor Stick Identification Test for Japanese(OSIT-J) and its relationship with pain-related SEPs was investigated.Results : There were no significant differences in N1 latencies or P1 latencies although N1/P1 peak-to-peak amplitudes were significantly lower(p<0. 05) in PD patients than in control subjects. In PD patients, there were significant correlations between N1/P1 amplitudes and disease duration(r=-0. 35, p<0. 05), Hoehn-Yahr stage(r=-0. 38, p<0. 05) and UPDRS part III(r=-0. 42, p<0. 01). Furthermore, the OSIT-J scores correlated with SEP amplitude(r=0. 41, p<0. 01).Conclusion : Pain processing in PD patients was impaired under specific nociceptive stimulation of Aδfibers and significant correlation with smell dysfunction was detected. We suggest that this mechanism may involve the limbic system during PD pathology.

背景和目的：许多非运动症状与帕金森氏病（PD）有关。其中，疼痛和嗅觉疾病往往是常见的前症状。尽管尚未完全了解潜在的机制，但PD已被证明存在异常中心疼痛处理。为了进一步研究这一点，我们通过特异性的AΔ刺激效果评估了PD患者，并确定了嗅觉功能。方法：42名患者（182名男性和24名女性），PD和11名健康对照组受试者（8名男性和3个女性）。使用细针电极刺激表皮AΔFiber，并记录在顶点处的体感（SEP）。使用日语的气味棒识别测试（OSIT-J）评估了嗅觉功能，并研究了与疼痛相关的SEP的关系。尽管在PD患者中，N1/P1峰值峰值放大器在N1潜伏期或P1潜伏期中没有显着差异（N1/P1峰值峰值放大器（P <0.05.05）。在PD患者中，N1/P1放大器与疾病持续时间之间存在显着相关性（r =-0。35，p <0。0.05），Hoehn-yahr阶段（r =-0。38，p <0。0.05）和UPDRS III（r =-0。42，p <0.01）。此外，OSIT-J评分与SEP放大器相关（r =0。41，p <0。0.01）。结论：在特异性伤害性刺激AΔFibers和与气味功能障碍的显着相关性下，PD患者的疼痛处理受损。我们建议这种机制可能涉及PD病理期间的边缘系统。

项目成果

パーキンソン病の酸化ストレスマーカーとしての8-OHdGと臨床症状との関連

氧化应激标志物8-OHdG与帕金森病临床症状的关系

• 发表时间: 2010
• 作者: Masaaki HIRAYAMA;Tetsuo HAMA;Takashi HARA;Tomohiko NAKAMURA;Gen SOBUE;Masaaki HIRAYAMA;濱哲夫,原敬史,中村友彦,平山正昭,祖父江元;濱哲夫(研究協力者);平山正昭
• 通讯作者: 平山正昭

Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease

• DOI: 10.1016/j.parkreldis.2010.11.004
• 发表时间: 2011-01-01
• 期刊: PARKINSONISM & RELATED DISORDERS
• 影响因子: 4.1
• 作者: Hirayama, Masaaki;Nakamura, Tomohiko;Sobue, Gen
• 通讯作者: Sobue, Gen

Pain related SEP and cortical SEP in Parkinson's disease Asian and Oceanian Par

亚洲和大洋洲帕金森病中疼痛相关的 SEP 和皮质 SEP

• 发表时间: 2011
• 作者: Masaaki HIRAYAMA;Tetsuo HAMA;Takashi HARA;Tomohiko NAKAMURA;Gen SOBUE
• 通讯作者: Gen SOBUE

Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials

• DOI: 10.1002/mus.22291
• 发表时间: 2012-02-01
• 期刊: MUSCLE & NERVE
• 影响因子: 3.4
• 作者: Hama, Tetsuo;Hirayama, Masaaki;Sobue, Gen
• 通讯作者: Sobue, Gen

PAIN RELATED SEP AND CORTICAL SEP IN PARKINSON'S DISEASE

帕金森病中与疼痛相关的 SEP 和皮质 SEP

• 发表时间: 2011
• 作者: Masaaki HIRAYAMA;Tetsuo HAMA;Takashi HARA;Tomohiko NAKAMURA;Gen SOBUE
• 通讯作者: Gen SOBUE