The role of regulatory T cell in Periodontitis regions

牙周细菌是牙周炎的病原体，但随后的进展和疾病的严重程度被认为是由宿主的免疫反应决定的。CD4^+CD25^+调节T细胞的存在可能在牙周炎的发生过程中起一定作用。本研究旨在探讨CD4+CD25+ Tr细胞在牙周炎中的作用。CD4^+CD25^+ Tr抑制CD4^+CD25- T细胞的增殖。Dynabeads HumanT-Activator CD3/CD28刺激CD4^+CD25^+ Tr后，抑制能力降低。这提示CD4^+CD25^+ Tr的抑制能力可能因刺激而降低。

Periodontal bacteria are the causative agents in periodontitis, but subsequent progression and disease severity are thought to be determined by the host immune responses. It was reported that CD4^+CD25^+ regulate T cell existed and might have roles in progress of periodontitis. The aim of this study was to make CD4+CD25+ Tr cell's roles in periodontitis. CD4^+CD25^+ Tr suppressed proliferation of CD4^+CD25- T cells. After CD4^+CD25^+ Tr was stimulate by Dynabeads HumanT-Activator CD3/CD28, The ability of suppression was reduced. This was suggested that the ability of suppression in CD4^+CD25^+ Tr might be reduced by the stimulation.