Development of an Educational Program Regarding the Prevention of Clostridium difficile Infection for Pediatric Cancer Patients

制定关于预防儿童癌症患者艰难梭菌感染的教育计划

• 批准号: 21792283
• 负责人: MURABATA Mayumi
• 金额: $ 2.83万
• 依托单位: Mie University (2011)Aichi Medical University (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792283/
• 关键词: 感染予防看護; 長期入院; 小児がん; Clostridium difficile; 予防ケア; 教育プログラム; Clostridium diffcile

We investigated intestinal colonization by C. difficile in children undergoing antineoplastic chemotherapy. The environmental surfaces of the pediatric ward where they were hospitalized were sampled and examined for the presence of C. difficile.C. difficile was recovered from 13 of the 15 children examined, and 2 of them were given the diagnosis of C. difficile infection and treated by vancomycin. C. difficile isolates were analyzed by PCR ribotyping. Ten patients had four PCR ribotype, which indicates nosocomial spreading in the ward. A total of 502 environmental surfaces were examined and 39 were positive for C. difficile. The 39 C. difficile isolates were classified into 18 different PCR ribotypes. The same PCR ribotype was recovered from stool specimens of 2 patients as well as from environmental surfaces of their room. These findings indicate that environmental contamination may contribute to C. difficile transmission among pediatric cancer patients.

我们调查了艰难梭菌在接受抗肿瘤化疗的儿童中的肠道定植情况。对他们住院的儿科病房的环境表面进行采样并检查艰难梭菌的存在。在接受检查的15名儿童中，有13名儿童恢复了艰难梭菌，其中2人被诊断为艰难梭菌感染，并接受了万古霉素治疗。艰难梭菌分离株采用聚合酶链式反应核糖体分型技术进行分析。10例患者有4个聚合酶链式反应核型，这表明医院感染在病房蔓延。总共检查了502个环境表面，39个环境表面艰难梭菌呈阳性。39株艰难梭菌被分成18个不同的核糖核型。从2名患者的粪便标本以及他们房间的环境表面中提取到相同的PCR型核糖体。这些发现表明，环境污染可能导致艰难梭菌在儿童癌症患者中的传播。

项目成果

Intestinal colonization of Clostridium difficile in pediatric cancer patients and the contamination of the ward environment with this orgamism

艰难梭菌在儿科癌症患者的肠道定植及其对病房环境的污染

• 发表时间: 2010
• 作者: Mayumi Murabata,Haru Kato,Hisako Yano,Yukio Wakimoto,Kazuki Oinishi;Mieko Kobayashi,Takao Deguchi,Tadashi Kumamoto ;Shoutarou Iwamoto ;Yoshichika Arakawa,Yoshihiro Komada
• 通讯作者: Yoshichika Arakawa,Yoshihiro Komada

長期入院がん患児療養環境における Clostridium difficile 汚染

长期住院癌症患者护理环境中的艰难梭菌污染

• 发表时间: 2010
• 作者: Mayumi Murabata,Haru Kato,Hisako Yano,Yukio Wakimoto,Kazuki Oinishi;Mieko Kobayashi,Takao Deguchi,Tadashi Kumamoto ;Shoutarou Iwamoto ;Yoshichika Arakawa,Yoshihiro Komada;村端真由美,矢野久子,脇山直樹,脇本幸夫,相楽弘文,加地千春,加藤はる;村端真由美,矢野久子,脇山直樹,三輪信彦,脇本幸夫,相楽弘文,加藤はる
• 通讯作者: 村端真由美,矢野久子,脇山直樹,三輪信彦,脇本幸夫,相楽弘文,加藤はる

感染症の看護とケアのポイント クロストリジウム・ディフィシル(Clostridium difficile)感染予防と看護

传染病的护理要点 艰难梭菌感染的预防与护理

• 发表时间: 2011
• 期刊: 化学療法の領域
• 作者: Chikae YAMAGUCHI;Midori ASANO;村端真由美
• 通讯作者: 村端真由美

感染症の看護とケアのポイントクロストリジウム・ディフィシル(Clostridium difficile)感染予防と看護

传染病的护理要点 艰难梭菌感染的预防与护理

• 发表时间: 2011
• 期刊: 化学療法の領域
• 作者: Chikae YAMAGUCHI;Midori ASANO;村端真由美;村端真由美
• 通讯作者: 村端真由美

長期入院がん患児の療養環境における Clostridium difficile の伝播に関する検討

癌症儿童长期住院治疗环境中艰难梭菌传播的研究

• 发表时间: 2010
• 作者: Mayumi Murabata,Haru Kato,Hisako Yano,Yukio Wakimoto,Kazuki Oinishi;Mieko Kobayashi,Takao Deguchi,Tadashi Kumamoto ;Shoutarou Iwamoto ;Yoshichika Arakawa,Yoshihiro Komada;村端真由美,矢野久子,脇山直樹,脇本幸夫,相楽弘文,加地千春,加藤はる
• 通讯作者: 村端真由美,矢野久子,脇山直樹,脇本幸夫,相楽弘文,加地千春,加藤はる