Comprehensive analysis of eosinophil-specific mRNA expression profiles
Comprehensive analysis of eosinophil-specific mRNA expression profiles
批准号:
20591196
负责人:
MATSUMOTO Kenji
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The number of eosinophils is well known to be one of the best clinical markers for assessing the severity of allergic inflammation; however, the precise roles of eosinophils in vivo remain unclear. In the present study we comprehensively analyzed mRNA expression profiles of eosinophils after exposure to various cytokines, chemokines and immobilized immunoglobulins, and compared them with those of human blood cells. As a result, we identified a number of genes specifically expressed in human eosinophil. Those included cytokines and chemokines, suggesting that eosinophils may play important roles not only as effecter cells but also as regulatory cells in vivo.
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DOI:
10.1165/rcmb.2009-0418oc
发表时间:
2011-06-01
期刊:
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
影响因子:
6.4
作者:
[Harada, Michishige, Hirota, Tomomitsu, Tamari, Mayumi]
通讯作者:
Tamari, Mayumi
DOI:
10.1159/000210652
发表时间:
2009-01-01
期刊:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
影响因子:
2.8
作者:
[Matsumoto, Kenji, Fukuda, Shuhei, Saito, Hirohisa]
通讯作者:
Saito, Hirohisa
beta(2)-adrenoceptor agonists enhance cytokine-induced release of thymic stromal lymphopoietin by lung tissue cells.
β(2)-肾上腺素受体激动剂增强细胞因子诱导的肺组织细胞胸腺基质淋巴细胞生成素的释放。
DOI:
--
发表时间:
2010
期刊:
Int Arch Allergy Immunol. 152
影响因子:
--
作者:
[Futamura K, Orihara K, Hashimoto N, Morita H, Fukuda S, Sagara H, Matsumoto K, Tomita Y, Saito H, Matsuda A.]
通讯作者:
Matsuda A.
アレルギー性炎症における好酸球-集積機序と病的意義の再考
过敏性炎症中的嗜酸性粒细胞——重新思考其积累机制和病理意义
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Shirou Maruyama, Youhei. Tanaka, Hiroshi. Sakamoto. Masayuki. Takeda, 松本健治]
通讯作者:
松本健治
Defining cell identity by comprehensive gene expression profiling.
通过全面的基因表达谱定义细胞身份。
DOI:
--
发表时间:
2010
期刊:
Curr Med Chem. 17
影响因子:
--
作者:
[Toyoda M, Hamatani T, Okada H, Matsumoto K, Saito H, Umezawa A.]
通讯作者:
Umezawa A.
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海外基金