Development of New Catalytic Control Methods of Chemoselectivity Using Multinuclear Metal Clusters

我们成功地开发了（1）三氟乙酸加合物-桥联四核锌簇的实用合成方法，（2）锌簇催化的乙酰化和脱乙酰化反应，（3）通过加成烷基胺或N-杂环化合物来加速锌簇催化的酯交换反应，（4）温和条件下铂催化的烯丙醇直接胺化反应，（5）Au催化的高官能化含氮亲核试剂对羟基的直接取代反应;（6）Rh-Phebox催化的α-酮酸酯的C1-对称不对称炔基化反应等。

We succeeded in the development of(1) practical synthetic method of Trifluoroacetic Acid Adduct of Trifluoroacetate-Bridged Tetranuclear Zinc Cluster,(2) the Zn cluster-catalyzed acetylation and deacetylation reactions,(3) acceleration of the Zn cluster-catalyzed transesterification by the addition of alkylamines or N-heterocyclic compounds,(4) Pt-catalyzed direct amination of allylic alcohols under mild conditions,(5) Au-catalyzed direct substitution of the hydroxy group with highly functionalized nitrogen nucleophiles,(6) C1-Symmetric Rh-Phebox-Catalyzed Asymmetric Alkynylation ofα-Keto Ester, and so on.