Roles of VEGF type 1 receptor signaling in pathologicalangiogenesis/lymphangiogenesis
Roles of VEGF type 1 receptor signaling in pathologicalangiogenesis/lymphangiogenesis
批准号:
21390072
负责人:
MAJIMA Masataka
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012
中文摘要
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英文摘要
Vascular endothelial growth factor (VEGF) is known as a major propangiogenic factor. VEGF has 3 receptors, namely VEGFR1 (Flt-1), VEGFR2 (Flk-1/KDR) and VEGFR3 (Flt-4). We had previously reported that the magnitude of cytokine-mediated release of SDF-1 from platelets and the recruitment of nonendothelial CXCR4+ VEGFR1+ hematopoietic progenitors, ‘hemangiocytes,’ constitute the major determinant of angiogenesis. We tested that Flt-1 Tyrosine Kinase (TK) signaling enhances angiogenesisby stimulating Stem Cell Factor (SCF) and MMP-9 by bone marrow stem cells. Blood flow recovery in TKKO was significantly delayed compared to WT. Compared to WT, plasma concentrations of SCF and pro-MMP9 were significantly reduced in TKKO. There was no significant difference between the concentrations of VEGF in both mice, but in TKKO, platelets-deposited microvascular density was significantly suppressed. These results suggested that the signaling of the Flt-1 is essential for recovering from acute ischemic conditions. Administration of selective VEGFR1 agonist may be useful to treat the ischemia, and may become a novel therapeutic strategy in regenerative cardiovascular medicine.
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Estimating the contribution of genes to variation in renal drug clearance by active secretionusing multiple data from clinical phase I studies
使用临床 I 期研究的多个数据估计基因对主动分泌引起的肾脏药物清除率变化的贡献
DOI:
10.1177/0091270009348502
发表时间:
2010
期刊:
J Clin Pharmacol
影响因子:
2.9
作者:
[Fujita T, Kumagai Y, Nakahara I, Ohtani Y, Majima M]
通讯作者:
Majima M
Heterogeniety of endothelial cells : Thromboxane-dependent platelet adhesion and angiogenesis
内皮细胞的异质性:血栓素依赖性血小板粘附和血管生成
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[古川鋼一, 大海雄介, 田島織絵, 大川祐樹, 徳田典代, 古川圭子, Majima M]
通讯作者:
Majima M
DOI:
10.1152/ajpgi.00013.2010
发表时间:
2010-11-01
期刊:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
影响因子:
4.5
作者:
[Ae, Takako, Ohno, Takashi, Majima, Masataka]
通讯作者:
Majima, Masataka
DOI:
10.2492/inflammregen.31.316
发表时间:
2011
期刊:
Inflammation and Regeneration
影响因子:
8.1
作者:
[H. Katoh;K. Hosono;Tatsunori Suzuki;M. Watanabe;M. Majima]
通讯作者:
H. Katoh;K. Hosono;Tatsunori Suzuki;M. Watanabe;M. Majima
DOI:
10.1254/jphs.09262fp
发表时间:
2010-02-01
期刊:
JOURNAL OF PHARMACOLOGICAL SCIENCES
影响因子:
3.5
作者:
[Kato, Shintaro, Amano, Hideki, Majima, Masataka]
通讯作者:
Majima, Masataka
共 45 条
Lymphangiogenesis as a regulator of fluid homeostasis in pathological settings
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批准号:24659119
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2012
-
负责人:MAJIMA Masataka
-
依托单位:
Roles of humoral and neural factors in angiogenesis and lymphangiogenesis in pathological conditions and their significance in molecular targeting therapy
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批准号:15390084
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.26万
-
财政年份:2003
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负责人:MAJIMA Masataka
-
依托单位:
Roles of inducible cyclooxvgenase-2 in angiogenesis and its significance of therapeutic targets
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批准号:12470529
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.07万
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财政年份:2000
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负责人:MAJIMA Masataka
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依托单位:
Preventive roles of renal Kallikrein-kinin system for hypertension
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批准号:07672472
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.6万
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财政年份:1995
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负责人:MAJIMA Masataka
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依托单位:
Development of a novel anti-hypertensive agent acting through the inhibition of urinary kininase.
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批准号:05671904
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.96万
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财政年份:1993
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负责人:MAJIMA Masataka
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依托单位:
海外基金