Analysis of regulatory molecule on vascular aging

在这里，我们展示了SNCA在葡萄糖代谢中的功能，这是帕金森病的易感基因。在日本人群的横向研究中，我们发现血清SNCA与血清胰岛素抵抗指标升高呈强负相关。此外，SNCA基因敲除小鼠在饮食诱导的胰岛素抵抗期间显示葡萄糖和胰岛素反应的明显改变。在这项研究中，我们还在日本人中进行了全基因组病例对照关联研究。分析显示，氧固醇结合蛋白OSBPL10（氧固醇结合蛋白样10）中的一个非编码SNP与PAD显著相关。我们在另一组公共体检中重复了这种关联，发现该cSNP的非风险等位基因与低血清LDL胆固醇水平相关，与年龄、性别和体重指数无关。

Here we show SNCA’s function in the glucose metabolism, which is a susceptible gene for Parkinson’s disease. In a transversal study in Japanese population, we found that serum SNCA was strongly inversely correlated with elevated seric insulin resistance indicators. Additionally, SNCA knock-out mice displayed evident alterations in glucose and insulin response during dietary-induced insulin resistance. In this study, we also performed a genome-wide case-control association study in Japanese individuals. The analysis showed that a non-coding SNP in a member of the oxysterol binding proteins, OSBPL10 (oxysterol binding protein like 10), was significantly associated with PAD. We replicated the association in another panel of public medical examinations, andfound that the non-risk allele of this cSNP correlated with a low serum LDL cholesterol levelindependent of age, sex and body mass index.