Analysis of regulatory molecule on vascular aging

血管衰老调控分子分析

• 批准号: 21390223
• 负责人: KATSUYA Tomohiro
• 金额: $ 11.32万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390223/
• 关键词: 老化; インスリン抵抗性; 肥満; 脂質異常

Here we show SNCA’s function in the glucose metabolism, which is a susceptible gene for Parkinson’s disease. In a transversal study in Japanese population, we found that serum SNCA was strongly inversely correlated with elevated seric insulin resistance indicators. Additionally, SNCA knock-out mice displayed evident alterations in glucose and insulin response during dietary-induced insulin resistance. In this study, we also performed a genome-wide case-control association study in Japanese individuals. The analysis showed that a non-coding SNP in a member of the oxysterol binding proteins, OSBPL10 (oxysterol binding protein like 10), was significantly associated with PAD. We replicated the association in another panel of public medical examinations, andfound that the non-risk allele of this cSNP correlated with a low serum LDL cholesterol levelindependent of age, sex and body mass index.

在这里，我们展示了SNCA在葡萄糖代谢中的作用，这是帕金森病的易感基因。在日本人群的一项横向研究中，我们发现血清SNCA与血清胰岛素抵抗指标的升高呈强烈的负相关。此外，SNCA基因敲除小鼠在饮食诱导的胰岛素抵抗过程中表现出明显的血糖和胰岛素反应变化。在这项研究中，我们还对日本人进行了全基因组病例对照关联研究。分析表明，氧固醇结合蛋白中的一个非编码SNP OSBPL10(氧固醇结合蛋白样蛋白10)与PAD显著相关。我们在另一组公共医疗检查中重复了这种关联，发现这种cSNP的非危险等位基因与低血清低密度脂蛋白水平相关，与年龄、性别和体重指数无关。

项目成果

Variation in OSBPL10 is associated with dyslipidemia

• DOI: 10.1038/hr.2010.28
• 发表时间: 2010-05
• 期刊: Hypertension Research
• 影响因子: 5.4
• 作者: H. Koriyama;H. Nakagami;T. Katsuya;H. Akasaka;S. Saitoh;K. Shimamoto;T. Ogihara;Y. Kaneda;R. Morishita;H. Rakugi

Identification of Evidence Suggestive of an Association with Peripheral Arterial Disease at the OSBPL10 Locus by Genome-Wide Investigation in the Japanese Population

• DOI: 10.5551/jat.4291
• 发表时间: 2010-01-01
• 期刊: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
• 影响因子: 4.4
• 作者: Koriyama, Hiroshi;Nakagami, Hironori;Morishita, Ryuichi
• 通讯作者: Morishita, Ryuichi

コレステロール代謝・輸送系制御機構における細胞機能・老化の解析

胆固醇代谢及转运系统控制机制中细胞功能与衰老的分析

• 发表时间: 2012
• 作者: 勝谷友宏;郡山弘;中神啓徳;森下竜一
• 通讯作者: 森下竜一

Alpha-synuclein is associated with impaired glucose regulation and insulin resistance

α-突触核蛋白与葡萄糖调节受损和胰岛素抵抗有关

• 发表时间: 2011
• 作者: 多田素久;横須賀收;金井文彦;他;中神啓徳
• 通讯作者: 中神啓徳

Dyslipidemia - From Prevention to Treatment, Chapter 7, Functions of OSBP/ORP Family Proteins and Their Relation to Dyslipidemia

血脂异常 - 从预防到治疗，第 7 章，OSBP/ORP 家族蛋白的功能及其与血脂异常的关系

• 作者: Koriyama H;Nakagami H;Katsuya T;Morishita R
• 通讯作者: Morishita R