Roles of Angiotensin II Receptor-Associated Protein in Vascular Senescence

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Angiotensin II mediates various effects through complex signaling pathways on binding to its G-protein-coupled receptors(GPCRs), the angiotesin II type 1(AT1) receptor and type 2(AT2) receptor. These receptors are regulated by GPCR-interacting proteins such as AT1 receptor-associated protein(ATRAP), and AT2 receptor-interacting protein(ATIP), which we have cloned. In this study, we demonstrated that ATRAP and ATIP negatively regulated vascular smooth muscle cell(VSMC) senescence in concert with the cross-talk of each angiotensin II receptor subtype.