Synthesis of Heterocyclic Compounds via Decarbonylative Cycloadditions

过渡金属催化的不饱和碳-碳键向杂环化合物碳-杂原子键的插入反应是一步制备更复杂杂环化合物的有用转化。然而，这种有潜在价值的方法还没有先例。我们假设环羰基化合物对镍(0)的氧化加成和随后的脱羰基化是容易的，并且可能允许插入炔。因此，我们开发了用镍(0)催化剂将酸酐脱碳加成成杂环化合物，该杂环化合物具有广泛的生物活性。

The transition metal-catalyzed insertion reaction of an unsaturated carbon-carbon bond into a carbon-hetero atom bond of an heterocyclic compound is a useful transformation to prepare a more complicated heterocyclic compounds in a single step. However, there is no precedent for such a potentially valuable methodology. We postulated that oxidative addition of cyclic carbonyl compounds to nickel(0) and subsequent decarbonylation are facile and might allow insertion of alkynes. Thus, we developed the decarbonylative addition of anhydrides to alkynes using nickel(0) catalyst to form hetero cyclic compounds, which displays a wide range of biological activities.