Exfoliation of gastric pit-parietal cells into the gastric lumen associated with a stimulation of acid-secretion observed in isolated rat gastric mucosa model.

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Gastric parietal cells of the gastric gland(especially at the pit) are highly differentiated cells responsible for the gastric hydrochloric acid secretion into the lumen of the stomach. We have recently noted that a number of pit-parietal cells were exfoliated into the lumen of isolated rat gastric mucosa model, and applied the cryo-techniques to elucidate the fine structure and histochemical characteristics in the process of cell exfoliation. Quantitative analysis verified a time-dependent increase in the number of cell exfoliation in the gastric mucosa isolated under acid-stimulation by histamine treatment compared with under acid-inhibition by H2-antagonist or proton pump inhibitor(PPI) treatment. Furthermore, an in vitro preliminary model of gastric erosion has been established with NSAIDs(Non-Steroidal Anti-Inflammatory Drugs) treatment. Acceleration of the cell exfoliations may result in the breakdown of gastric epithelial continuities. Therefore the sealing of the basal spot of exfoliated pit-parietal cells by neighboring mucous cells seems profitable to prevent an epithelial deficiency leading to gastric erosion and ulcer.