Identification of microRNAs regulating apoptosis and elucidation of their role in carcinogenesis.
Identification of microRNAs regulating apoptosis and elucidation of their role in carcinogenesis.
批准号:
21790533
负责人:
TATSUMI Naoya
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
We found that the expression of WT1 was suppressed in Doxorubicin (Dox)-induced apoptosis in a concentration-dependent manner. Cloning of small RNAs expressed in DOX-treated gastric cancer cells revealed twenty-two miRNAs that increased in their expression levels during this process. Among them, we identified miR-A as a miRNA that could target WT1 and regulate apoptosis. Moreover, we showed that the expression of miR-A could be a prognostic factor for non-small cell lung cancers.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ウイルムス腫瘍遺伝子WT1の腫瘍血管内皮細胞における発現
肾母细胞瘤基因WT1在肿瘤血管内皮细胞中的表达
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[福田茉莉, 尾路祐介, 中塚伸一, 岡芳弘, 坪井昭博, 保仙直毅, 西田純幸, 辰巳直也, 青笹克之, 杉山治夫]
通讯作者:
杉山治夫
DOI:
10.3892/ijo_00000246
发表时间:
2009-05-01
期刊:
INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子:
5.2
作者:
[Nakamura, Junya, Aoyagi, Sayaka, Oji, Yusuke]
通讯作者:
Oji, Yusuke
Identification of microRNAs regulating apoptosis and elucidation of their roles in tumorigenesis
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批准号:23790622
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
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财政年份:2011
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负责人:TATSUMI Naoya
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依托单位:
海外基金