Effect of Thyrotropin-releasing hormone on gene expression in the islet of Langerhans of the pancreas

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Thyrotropin-releasing hormone (TRH) is ubiquitously distributed throughout the brain and other tissues including pancreas. We have reported that the TRH-deficient mice (TRH^<-/->) showed characteristic tertiary hypothyroidism and also hyperglycemia, which was accompanied by impaired insulin secretion in response to glucose. To elucidate the molecular mechanism of TRH effect on insulin secretion, we conducted a microarray study with endocrine islets of mice pancreas. In the microarray analysis, 7827 genes with proper expression levels were detected in islets isolated from both TRH^<-/-> and wild type mice.